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Fig. 1 | Respiratory Research

Fig. 1

From: Serum extracellular vesicular miR-21-5p is a predictor of the prognosis in idiopathic pulmonary fibrosis

Fig. 1

Circulating EVs increased during the acute phase of the experimental bleomycin-induced lung fibrosis model. a Detection of mouse CD9-positive pan-EVs by ExoScreen. Correlation between ExoScreen measurements for CD9-positive pan-EVs and EV protein concentration in a dilution series. EVs were purified from a mouse lung cancer cell line (Lewis lung carcinoma (LLC, left)) or a mouse mesenchymal cell line (KUM-10, right). Error bars are SEM; n = 3 for each condition. b Detection of circulating EVs in mouse sera. Correlation between ExoScreen measurements for CD9-positive pan-EVs and serum volume in a dilution series. Error bars are SEM; n = 3 for each condition. c Serum levels of CD9-positive pan-EVs in an experimental BLM-induced lung fibrosis model. Two microliters of serum from each mouse were used for the detection of EVs by ExoScreen. Note that the levels of pan-EVs were significantly higher in sera from mice at 7 days compared with those in non-treated (NT) mice. Error bars are SEM (n = 9 for each time point). The data were assessed for significance using the Kruskal-wallis test for multiple comparisons. *, p < 0.05 vs. NT mice

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Respiratory Research

ISSN: 1465-993X

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