Step | Criterion for sequential selection | NCT02172287 | NCT00274014 | NCT00274547 | NCT00277264 | NCT00144339 | NCT00387088 | NCT00563381 | NCT01126437 | NCT01455129 | Median |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | FEV1 | 46.8 | 50.3 | 46.8 | 56.3 | 65.8 | 46.8 | 65.8 | 65.8 | 72.8 | 56.3 |
2 | Other inclusion criteria | 38.5 | 20.6 | 44.5 | 23.2 | 54.4 | 44.5 | 26.1 | 55.6 | 64.7 | 44.5 |
3 | COPD-related exclusion criteria | 37.8 | 19.9 | 41.6 | 21.8 | 53.4 | 43.8 | 25.8 | 54.4 | 59.8 | 41.6 |
4 | Concomitant pulmonary disease | 35.6 | 19.9 | 41.6 | 20.2 | 47.3 | 41.1 | 25.5 | 48.2 | 52.9 | 41.1 |
5 | Asthma, allergic diseases and atopy | 23.8 | 14.3 | 32.9 | 14.7 | 37.5 | 29.8 | 19.6 | 38.2 | 39.1 | 29.8 |
6 | Comorbidities | 16.7 | 11.2 | 30.7 | 9.6 | 28.8 | 27.9 | 15.2 | 29.3 | 31.4 | 27.9 |
7 | Other relevant conditions | 15.7 | 11.2 | 30.7 | 9.5 | 27.1 | 27.9 | 14.4 | 27.5 | 29.2 | 27.1 |
8 | Final eligible proportion (%) | 15.7 | 11.2 | 25.1 | 9.5 | 22.5 | 27.8 | 11.8 | 22.9 | 25.0 | 22.5 |