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Table 2 Inhibition of cytokine production by dexamethasone, tofacitinib and PIK-294 in TCR-stimulated BAL cells from asthma patients and healthy subjects

From: Anti-inflammatory potential of PI3Kδ and JAK inhibitors in asthma patients

Compound

Cytokine

IC35 values (nM)

IC50 values (nM)

Mean % inhibition at 10 μM +/− SD

Healthy

Asthma

Healthy

Asthma

Healthy

Asthma

Dexamethasone

IFNγ

2.6

3.4

7.6

28.7

75.2 +/− 20.8

69.1 +/− 26.7

IL-13

<1.0a

<1.0a

1.1

1.2

96.6 +/− 6.8

77.3 +/− 31.1

IL-17

8.7

267.8

1098

>10,000b

57.6 +/− 15.3

45.8 +/− 21.7

Tofacitinib

IFNγ

56.8

56.7

135.2

141.1

96.1 +/− 2.9

94.9 +/− 7.2

IL-13

24.8

26.5

48.8

75.6

85.8 +/− 9.4

90.0 +/− 11.5

IL-17

297

1042

1321

2495

80.4 +/− 9.2

83.1 +/− 11.0

PIK-294

IFNγ

6.8

5.3

31.7

35.8

77.5 +/− 17.1

84.4 +/− 14.5

IL-13

1.3

<1.0a

19.0

31.2

87.4 +/− 9.3

93.0 +/− 5.5

IL-17

9.6

10.1

368.4

75.9

61.3 +/− 14.7

70.3 +/− 12.2

  1. Absolute IC35 and IC50 values calculated from the mean % inhibition for each drug concentration tested. aIC35 value uncalculatable as >35 % mean inhibition observed with 1.0 nM of drug; bIC50 value uncalculatable as <50 % mean inhibition observed with 10,000 nM of drug