From: Anti-inflammatory potential of PI3Kδ and JAK inhibitors in asthma patients
Compound | Cytokine | IC35 values (nM) | IC50 values (nM) | Mean % inhibition at 10 μM +/− SD | |||
---|---|---|---|---|---|---|---|
Healthy | Asthma | Healthy | Asthma | Healthy | Asthma | ||
Dexamethasone | IFNγ | 2.6 | 3.4 | 7.6 | 28.7 | 75.2 +/− 20.8 | 69.1 +/− 26.7 |
IL-13 | <1.0a | <1.0a | 1.1 | 1.2 | 96.6 +/− 6.8 | 77.3 +/− 31.1 | |
IL-17 | 8.7 | 267.8 | 1098 | >10,000b | 57.6 +/− 15.3 | 45.8 +/− 21.7 | |
Tofacitinib | IFNγ | 56.8 | 56.7 | 135.2 | 141.1 | 96.1 +/− 2.9 | 94.9 +/− 7.2 |
IL-13 | 24.8 | 26.5 | 48.8 | 75.6 | 85.8 +/− 9.4 | 90.0 +/− 11.5 | |
IL-17 | 297 | 1042 | 1321 | 2495 | 80.4 +/− 9.2 | 83.1 +/− 11.0 | |
PIK-294 | IFNγ | 6.8 | 5.3 | 31.7 | 35.8 | 77.5 +/− 17.1 | 84.4 +/− 14.5 |
IL-13 | 1.3 | <1.0a | 19.0 | 31.2 | 87.4 +/− 9.3 | 93.0 +/− 5.5 | |
IL-17 | 9.6 | 10.1 | 368.4 | 75.9 | 61.3 +/− 14.7 | 70.3 +/− 12.2 |