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Fig. 2 | Respiratory Research

Fig. 2

From: Circulating microparticles in severe pulmonary arterial hypertension increase intercellular adhesion molecule-1 expression selectively in pulmonary artery endothelium

Fig. 2

MPs from late-stage PAH rats increase the content of ICAM-1 in PAECs. PAECs were treated with 50ug/mL MPs from age matched control rats, 8-week (a), or 3-week (b) severe PAH rats. Surface (non-permeabilized cells) ICAM-1 was analyzed by flow cytometry and represented by representative dot plots and fold analysis. Whole cell (permeabilized) content of ICAM-1 was also analyzed (c and d; 8-week and 3-week, respectively). Eight-week, or late-stage, PAH MPs significantly increased both surface and whole cell ICAM-1 in PAECs, whereas 3-week PAH MPs did not. n = 5 * = p < 0.05, ** = p < 0.01

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