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Fig. 1 | Respiratory Research

Fig. 1

From: N-methyl-D-aspartate receptor activation mediates lung fibroblast proliferation and differentiation in hyperoxia-induced chronic lung disease in newborn rats

Fig. 1

Lung histology. Normal development of alveolarization is seen in the control group (a-d). 3 days’ 95 % hyperoxia induced a small number of inflammatory cells in some of the alveolar spaces compared with the air control group at day 4 (g vs a). By day 8, inflammatory cells in the alveolar spaces had disappeared, and fewer alveoli were observed relative to the air group (h vs b). Wider alveolar septa and fewer alveoli were seen than in the air group on postnatal day 15 (i vs c). On postnatal day 22, alveolar septa had widened and alveolar numbers had decreased more markedly, and lung fibroblast proliferation could be observed in hyperoxia group (j vs d). MK-801 treatment in hyperoxia exposure rats showed thinner alveolar septa, greater numbers of alveoli, and a lower degree of lung fibroblast proliferations compared with the air group at postnatal days 15 and 22 (k and l vs i and j, respectively). MK-801 had no macroscopic effects on normal rats (e and f vs c and d, respectively). (Hematoxylin and Eosin × 40. Bar is 100 μm)

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Respiratory Research

ISSN: 1465-993X

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