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Fig. 3 | Respiratory Research

Fig. 3

From: N-methyl-D-aspartate receptor activation mediates lung fibroblast proliferation and differentiation in hyperoxia-induced chronic lung disease in newborn rats

Fig. 3

MK-801 treatment during recovery from acute injury inhibited hyperoxia-induced pulmonary fibroplasia in newborn rats. MK-801 treatment on days 8 to 10 in hyperoxia exposure rats exhibited less level of HYP (a) and type I procollagen mRNA expression (b), and a greater RAC (c) at days 15 and 22 (P < 0.05 or 0.01 respectively), as well as a greater improvement in Cdyn (P < 0.01) at day 22 (d) than the hyperoxia group. Moreover, MK-801 had no significant influence on HYP and RAC, but depressed Cdyn in normal rats (d). H: hyperoxia group; C: control group; M: air + MK-801 group; HM: hyperoxia + MK-801 group; HYP: hydroxyproline; Cdyn: dynamic lung compliance; RAC: Radial alveolar count; PC I: type I procollagen. **P <0.01 vs. air group; † P < 0.05, †† P < 0.01 vs. hyperoxia group, n = 6 per group

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