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Fig. 4 | Respiratory Research

Fig. 4

From: N-methyl-D-aspartate receptor activation mediates lung fibroblast proliferation and differentiation in hyperoxia-induced chronic lung disease in newborn rats

Fig. 4

Upregulation of NR2 mRNA in lung fibroblasts of hyperoxia-exposed newborn rats. The mRNA levels of NR1 and the four NR2 subtypes (A, B, C, and D) in the lung fibroblasts of newborn rats were detected using real-time PCR. NR1 and NR2A were the dominant subtypes compared with other NR2 subtypes, NR2B and NR2D were moderately expressed, and NR2C expression was barely detectable. Hyperoxia had no influence on NR1, but upregulated the mRNA levels of all the NR2s (P < 0. 01), especially NR2A and NR2D. H: hyperoxia group; C: control group; NR1: NMDAR 1; NR2 A: NMDAR 2A; NR2 B: NMDAR 2B; NR2 C: NMDAR 2C; NR2 D: NMDAR 2D. **P <0.01 vs. air group, n = 6 per group

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Respiratory Research

ISSN: 1465-993X

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