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Fig. 2 | Respiratory Research

Fig. 2

From: WNT signaling – lung cancer is no exception

Fig. 2

Mechanism of WNT secretion. WNT ligand is secreted in the endoplasmatic reticulum (ER) and palmitoylated by Porcupine (PORC). a After releasing from the ER palmitolyated WNT enters the Golgi apparatus and Wls-coupled WNT travels to the plasma membrane. Then Wls is recycled from the plasma membrane and the retromer complex shuttles it back to the Golgi. b WNT-Wls complex can be transferred to the microvesicular body. Exosome can be produced from MVB that serves as a source of WNTs for long-range spread. c Reggie-1/Flotillin-2 can mediate the re-endocytosis of WNT molecules and may facilitate the transport of a more soluble micella-like form of WNTs [89]

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