Table 2 miRNAs regulating WNT signaling in LC

miR-34a

Inhibits beta-catenin activity

[200]

miR-17-92

Increases beta-catenin activity

[201]

miR-21

Increases beta-catenin expression

[202]

miR-27b

Upregulated by WNT5a, inhibits vascular branching

[134]

miR-29

Downregulates beta-catenin expression

[203]

miR-31

Decreases WNT antagonists and increases WNT5a

[119]

miR-191

Increases beta-catenin pathway activation

[204]

miR-374a

Targets WNT5a

[205]

miR-376c

Suppresses canonical WNT signaling

[117]

miR-410

Activates beta-catenin pathway

[118]

miR-487b

Reduces WNT5a activity

[114]

miR-544a

Downregulates GSK3beta

[206]

miR-574-5p

Enhances beta-catenin phosphorlyation

[207]

miR-708

Increases canonical WNT signaling

[208]