Fig. 1From: Intersectin-1s deficiency in pulmonary pathogenesisThe domain structure intersectin-1 (ITSN-1) proteins. ITSN-1 proteins are comprised of Eps15 homology (EH) domains, a coiled-coil (CC) region, and 5 consecutive Src homology 3 (SH3) domains (SH3A, SH3B, SH3C, SH3D, SH3E), each with distinct ligands. A longer splice variant, termed ITSN-1Â l, shares all the domains with the shorter spliced isoform, referred to as ITSN-1s, but in addition possesses a C-terminal extension encoding a Dbl-homology domain (DH), a pleckstrin homology (PH) domain and a C2 domainBack to article page