Fig. 1
From: Cardiovascular risk in patients with alpha-1-antitrypsin deficiency
The presence of AATD in males and female patients (broken line) is associated with a significant reduction of TLCO %pred as compared to patients with COPD (straight line). The multivariate analysis included adjustment for airway obstruction in terms of FEV1% pred, lung hyperinflation in terms of ITGV %pred and COPD risk factors in terms of packyears and BMI