Table 2 Pulmonary function measurements reveal difference between AATD-COPD and COPD
From: Cardiovascular risk in patients with alpha-1-antitrypsin deficiency
Total (2645) | 1 AATD + T (110) | 2 AATD- T (29) | 3 COPD (2506) | Diff. between means (CI 95%) p-value | |
|---|---|---|---|---|---|
FEV1 (L) | 1.65 (1.63–1.68) | 1.46 (1.32–1.59) | 2.11 (1.85–2.37) | 1.66 (1.63–1.68) | 1–2: −0.65 (−094–0.36) < .0001 1–3: −0.20 (−0.33–0.06) < .001 2–3: 0.45 (0.19 0.71) < .001 |
FEV1% predicted | 56.28 (55.84–57.08) | 45.14 (41.25–49.02) | 68.86 (61.29–76.43) | 56.62 (55.81–57.44) | 1–2: −23.72 (−32.2–15.2) < .0001 1–3: −11.50 (−15.4–7.5) < .0001 2–3: 12.3 (4.6 19.9) < .001 |
FVC % predicted | 78.55 (77.82–79.28) | 76.00 (72.42–79.55) | 85.70 (78.76–92.64) | 78.58 (77.83–79.33) | 1–2: −9.71 (−17.5–1.9) 0.014 1–3: −2.58 (−6.22 1.06) 0.164 2–3: 7.12 (0.14 14.10) 0.046 |
FEV1/VC | 0.55 (0.54–0.55) | 0.46 (0.44–0.49) | 0.61 (0.56–0.66) | 0.55 (0.55–0.56) | 1–2: −0.15 (−0.20–0.09) < .0001 1–3: −0.09 (−0.11–0.06) < .0001 2–3: 0.06 (0.01 0.10) 0.020 |
RV (L) | 3.82 (3.77–3.87) | 4.49 (4.26–4.7) | 3.70 (3.26–4.15) | 3.79 (3.75–3.84) | 1–2: 0.79 (0.29 1.29) 0.002 1–3: 0.69 (0.46 0.93) < .0001 2–3: −0.09 (−0.54 0.35) 0.685 |
RV/ TLC nominal value (%) | 134.10 (133.00–135.29) | 145.53 (140.15–150.91) | 127.76 (117.43–138.08) | 133.67 (132.54–134.80) | 1–2: 17.77 (6.12 29.42) 0.003 1–3: 11.85 (6.35 17.35) < .0001 2–3: −5.91 (−16.31 4.48) 0.265 |
ITGV % predicted | 145.13 (143.69–146.58) | 172.25 (165.29–179.22) | 148.02 (134.58–161.47) | 143.90 (142.43–145.36) | 1–2: 24.23 (9.09 39.38) 0.002 1–3: 28.35 (21.23 35.47) < .0001 2–3: 4.12 (−9.41 17.64) 0.550 |
TLC (L) | 7.13 (7.07–7.18) | 8.18 (8.00–8.46) | 7.46 (6.91–8.00) | 7.08 (7.02–7.14) | 1–2: 0.72 (0.11 1.33) 0.021 1–3: 1.11 (0.82 1.40) < .0001 2–3: 0.39 (−0.16 0.93) 0.165 |
sRaw eff % predicted | 170.90 (165.81–176.00) | 179.28 (154.29–204.27) | 120.75 (73.38–168.13) | 171.14 (165.91–176.37) | 1–2: 58.53 (4.94112.11) 0.032 1–3: 8.11 (−17.43 33.65) 0.534 2–3: −50.42 (−98.10–2.74) 0.038 |
TLCO % predicted | 55.01 (54.17–55.86) | 43.92 (39.79–48.05) | 56.49 (48.71–64.27) | 55.47 (54.61–56.33) | 1–2: −12.57 (−21.38–3.76) 0.005 1–3: −11.54 (− 15.77–7.33) < .0001 2–3: 1.02 (−6.82 8.85) 0.799 |