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Fig. 1 | Respiratory Research

Fig. 1

From: Beclomethasone dipropionate and formoterol fumarate synergistically interact in hyperresponsive medium bronchi and small airways

Fig. 1

Bliss Independence analysis (a and b) and delta effect between the observed and expected relaxant response (c and d) induced by BDP plus FF administered at 100:6 combination-ratio in non-sensitized (a and c) and passively sensitized (b and d) human medium bronchi submaximally contracted by histamine. *P < 0.05 and **P < 0.01 vs. the expected additive relaxant effect as predicted by BI equation (statistical significance assessed by Student’s t test); ##P < 0.01 and ###P < 0.001 vs. the expected additive relaxant effect as predicted by BI equation (statistical significance assessed by two-way ANOVA). Points represent the mean ± SEM of n = 5 sub-segmental bronchi from different subjects. BI: Bliss independence; BDP: beclomethasone dipropionate; FF: formoterol fumarate

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