Fig. 1From: Beclomethasone dipropionate and formoterol fumarate synergistically interact in hyperresponsive medium bronchi and small airwaysBliss Independence analysis (a and b) and delta effect between the observed and expected relaxant response (c and d) induced by BDP plus FF administered at 100:6 combination-ratio in non-sensitized (a and c) and passively sensitized (b and d) human medium bronchi submaximally contracted by histamine. *P < 0.05 and **P < 0.01 vs. the expected additive relaxant effect as predicted by BI equation (statistical significance assessed by Student’s t test); ##P < 0.01 and ###P < 0.001 vs. the expected additive relaxant effect as predicted by BI equation (statistical significance assessed by two-way ANOVA). Points represent the mean ± SEM of n = 5 sub-segmental bronchi from different subjects. BI: Bliss independence; BDP: beclomethasone dipropionate; FF: formoterol fumarateBack to article page