| BDP | FF |
---|
Medium bronchi | Bronchioles | Medium bronchi | Bronchioles |
---|
Emax | pEC50 | Emax | pEC50 | Emax | pEC50 | Emax | pEC50 |
---|
Non-sensitized | < 20% | NC | < 20% | NC | 97.00 ± 2.77% | 8.26 ± 0.07 | 72.03% ± 4.34# | 7.13 ± 0.11# |
Passively sensitized | < 20% | NC | < 20% | NC | 94.96 ± 1.22% | 8.89 ± 0.04*** | 105.30%*** | 7.52 ± 0.09*# |
- *P < 0.05 and ***P < 0.001 vs. non-sensitized airways of equal diameter, #P < 0.001 vs. medium bronchi undergoing the same treatment (statistical significance assessed by t-test). BDP Beclomethasone dipropionate, EC50 The concentration inducing 50% Emax, E
max
maximal effect, FF Formoterol fumarate, NC Not calculable, PCLS Precision cut lung slices, pEC
50
-LogEC50