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Table 5 Univariable analysis for cutoff points of Pulmonary Function tests and Pneumonitis

From: Abnormal pulmonary function tests predict the development of radiation-induced pneumonitis in advanced non-small cell lung Cancer

RTOG Scale

PFT

Cutoff point

No Pneumonitis

Pneumonitis

HR

95% CI

P value

FEV1

˂1.9

5 (19.2%)

4(36.4%)

1.35

0.72–2.51

0.404

≥1.9

21 (80.8%)

7 (63.6%)

FeNO

˂18.5

17 (65.4%)

1 (9.1%)

1.99

1.22–3.24

0.003

≥18.5

9 (34.6%)

10 (90.9%)

DLCO

˂16.9

6 (23.1%)

7 (63.6%)

1.81

0.97–3.34

0.028

≥16.9

20 (76.9%)

4 (36.4%)

CTCAE Scale

PFT

Cutoff point

No Pneumonitis

Pneumonitis

HR

95% CI

P value

FEV1

˂1.9

2 (9.1%)

7 (46.7%)

3.21

0.93–11.16

0.017

≥1.9

20 (90.9%)

8 (53.3%)

FeNO

˂17.5

13 (59.1%)

3 (20%)

1.90

1.10–3.28

0.041

≥17.5

9 (40.9%)

12 (80%)

DLCO

˂18.9

7 (31.2%)

12 (80%)

2.26

1.21–4.22

0.007

≥18.9

15 (68.2%)

3 (20%)

  1. FEV 1 forced expiratory volume in one second, FeNO Fraction of exhaled Nitric Oxide, DLCO Diffusing capacity of the lung for CO, HR Hazard ratio, CI confidence interval
  2. Significant P values in bold