Table 2 Genome-wide significant results of EWAS in whole blood
From: From blood to lung tissue: effect of cigarette smoke on DNA methylation and lung function
CpG-site | B | SE | P-value | Adj. P-value | Gene annotation | Gene function# |
|---|---|---|---|---|---|---|
cg05575921* | − 0.00360 | 0.00043 | 6.80E-17 | 2.86E-11 | AHRR | Repressor of AHR, important in dioxin toxicity and involved in regulation of cell growth and differentiation |
cg21566642* | − 0.00176 | 0.00024 | 1.21E-13 | 5.09E-08 | NA | NA |
cg03636183* | − 0.00211 | 0.00029 | 1.55E-13 | 6.53E-08 | F2RL3 | Plays a role in platelet activation and hypomethylation may be associated with human lung cancer |
cg05951221* | − 0.00130 | 0.00018 | 2.01E-13 | 8.48E-08 | NA | NA |
cg01940273* | − 0.00143 | 0.00020 | 4.20E-13 | 1.77E-07 | NA | NA |
cg06126421* | − 0.00230 | 0.00033 | 2.75E-12 | 1.16E-06 | NA | NA |
cg15342087* | − 0.00092 | 0.00014 | 1.23E-11 | 5.19E-06 | NA | NA |
cg24859433* | − 0.00089 | 0.00014 | 3.91E-11 | 1.65E-05 | NA | NA |
cg27241845* | − 0.00110 | 0.00018 | 2.21E-09 | 9.30E-04 | NA | NA |
cg20451986 | 0.00104 | 0.00018 | 4.85E-09 | 2.04E-03 | NA | NA |
cg12876356* | − 0.00244 | 0.00042 | 7.55E-09 | 3.18E-03 | GFI1 | Transcription repressor essential for hematopoiesis |
cg09935388* | − 0.00218 | 0.00040 | 5.42E-08 | 2.28E-02 | GFI1 | Transcription repressor essential for hematopoiesis |
cg21161138* | − 0.00106 | 0.00020 | 7.10E-08 | 2.99E-02 | AHRR | Repressor of AHR, important in dioxin toxicity and involved in regulation of cell growth and differentiation |
cg22994830 | 0.00102 | 0.00019 | 7.17E-08 | 3.02E-02 | PRKAR1B | Involved in cAMP signaling in cells |
cg18146737* | − 0.00256 | 0.00048 | 8.19E-08 | 3.45E-02 | GFI1 | Transcription repressor essential for hematopoiesis |