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Table 4 Effect of viral infection on nasal lavage mRNA and protein expression

From: Influence of viral infection on the relationships between airway cytokines and lung function in asthmatic children

 

Virus-negative

Virus-positive

 

mRNA

N

Median

IQR

N

Median

IQR

p-value

 CXCL8

404

4.68

(2.15, 9.71)

174

5.01

(2.45, 10.78)

0.54

 CXCL10

404

0.001

(0.00, 0.01)

174

0.0098

(0.001, 0.06)

< 0.01

 IRF7

404

0.06

(0.02, 0.14)

174

0.06

(0.02, 0.14)

0.99

 RIG-I

404

0.01

(0.00, 0.03)

174

0.02

(0.00, 0.05)

0.04

 MDA5

404

0.01

(0.00, 0.03)

174

0.02

(0.01, 0.07)

< 0.01

Binary

N

Detected (%)

 

N

Detected (%)

 

p-value

 TLR3

404

132/404 (32.7)

 

174

69 (39.7)

 

0.11

 IFN-λ1

404

30/404 (7.4)

 

174

33 (19.0)

 

< 0.01

Protein

N

Median

IQR

N

Median

IQR

p-value

 CXCL8

433

177.00

(71.5, 431.6)

172

253.35

(97.25, 868.9)

< 0.01

 CXCL10

429

397.90

(213.9, 656.2)

171

703.20

(419.5, 1553.5)

< 0.01

 IL-4

436

15.60

(4.9, 51.65)

175

31.10

(9.3, 75.2)

< 0.01

 IL-13

428

4.60

(0.0, 27.1)

167

18.80

(0.0, 37.8)

< 0.01

 sICAM1

431

293.20

(100.8, 643.6)

170

560.20

(207.6, 1219.2)

< 0.01

 CCL2

433

71.40

(26.9, 132.9)

170

103.70

(40.3, 219.6)

< 0.01

 CCL4

426

300.9

(40.3, 1261.9)

170

1198.65

(163.0, 3050.6)

< 0.01

 CCL5

433

5.00

(0.0, 18.1)

174

9.55

(0.0, 27.4)

< 0.01

 CCL20

439

290.3

(78.0, 651.1)

178

580.0

(186.1, 1184.5)

< 0.01

 CCL24

434

4.47

(1.06, 14.24)

175

9.16

(2.56, 21.06)

< 0.01

  1. Levels of mRNA expression are normalized to GAPDH. Group median data are shown except for TLR3 and IFN-λ1 mRNA, for which results were analyzed as binary variables. Samples were divided into virus-negative and virus positive. Differences were analyzed by the Wilcoxon Median Test except for TLR3 and IFN-λ1 which were analyzed by Fisher’s exact test