Table 2 Common respiratory manifestations by PID type
From: Primary immunodeficiency diseases in lung disease: warning signs, diagnosis and management
Common respiratory manifestations by PID type | N (Composition of panel) | Votes in agreement (%) | Degree of agreement |
|---|---|---|---|
Predominantly T cell deficiency (combined and PID-related syndromes) | |||
Recurrent bronchitis | 43 (AI, AP, PI, PP) | 72.1 | Majority |
Idiopathic bronchiectasis | 43 (AI, AP, PI, PP) | 76.7 | Majority |
Recurrent pneumonias* | 43 (AI, AP, PI, PP) | 88.4 | Consensus |
Repeated pneumonia in child | 43 (AI, AP, PI, PP) | 88.4 | Consensus |
Chronic bronchial infection | 43 (AI, AP, PI, PP) | 79.1 | Majority |
Prolonged antibiotic treatment with poor response | 43 (AI, AP, PI, PP) | 86.0 | Consensus |
Abscess and pneumatocele | 43 (AI, AP, PI, PP) | 55.8 | Discrepancy |
Infections caused by rare microorganisms | 43 (AI, AP, PI, PP) | 100.0 | Unanimity |
Pneumonitis or bronchitis with hospitalization in infants | 43 (AI, AP, PI, PP) | 86.0 | Consensus |
Interstitial lung disease | 43 (AI, AP, PI, PP) | 93.0 | Consensus |
Bronchiolitis obliterans | 43 (AI, AP, PI, PP) | 67.4 | Majority |
Alveolar proteinosis | 43 (AI, AP, PI, PP) | 76.7 | Majority |
Absent thymus or aplasia | 43 (AI, AP, PI, PP) | 95.3 | Consensus |
Antibody deficiencies | |||
Recurrent bronchitis | 43 (AI, AP, PI, PP) | 90.7 | Consensus |
Idiopathic bronchiectasis | 43 (AI, AP, PI, PP) | 97.7 | Consensus |
Recurrent pneumonias* | 43 (AI, AP, PI, PP) | 97.7 | Consensus |
Repeated pneumonia in child | 43 (AI, AP, PI, PP) | 97.7 | Consensus |
Chronic bronchial infection | 43 (AI, AP, PI, PP) | 90.7 | Consensus |
Prolonged antibiotic treatment with poor response | 43 (AI, AP, PI, PP) | 97.7 | Consensus |
Pneumonia due to encapsulated bacteria | 43 (AI, AP, PI, PP) | 97.7 | Consensus |
Interstitial lung disease | 43 (AI, AP, PI, PP) | 79.1 | Majority |
Bronchiolitis obliterans | 43 (AI, AP, PI, PP) | 60.5 | Discrepancy |
Pulmonary lymphoma | 43 (AI, AP, PI, PP) | 69.8 | Majority |
Thymoma | 43 (AI, AP, PI, PP) | 88.4 | Consensus |
Immune deregulation | |||
Recurrent bronchitis | 43 (AI, AP, PI, PP) | 69.8 | Majority |
Idiopathic bronchiectasis | 43 (AI, AP, PI, PP) | 74.4 | Majority |
Chronic bronchial infection | 43 (AI, AP, PI, PP) | 65.1 | Majority |
Pneumonia due to encapsulated bacteria | 43 (AI, AP, PI, PP) | 67.4 | Majority |
Interstitial lung disease | 43 (AI, AP, PI, PP) | 81.4 | Consensus |
Phagocyte disorders | |||
Recurrent pneumonias* | 43 (AI, AP, PI, PP) | 90.7 | Consensus |
Prolonged antibiotic treatment with poor response | 43 (AI, AP, PI, PP) | 88.4 | Consensus |
Abscess and pneumatocele | 43 (AI, AP, PI, PP) | 97.7 | Consensus |
Infections caused by rare microorganisms | 43 (AI, AP, PI, PP) | 97.7 | Consensus |
Alveolar proteinosis | 43 (AI, AP, PI, PP) | 69.8 | Majority |
Innate immunity disorder | |||
Recurrent pneumonias* | 43 (AI, AP, PI, PP) | 97.7 | Consensus |
Pneumonia due to encapsulated bacteria | 43 (AI, AP, PI, PP) | 95.3 | Consensus |
Abscess and pneumatocele | 43 (AI, AP, PI, PP) | 83.7 | Consensus |
Infections caused by rare microorganisms | 43 (AI, AP, PI, PP) | 90.7 | Consensus |
Complement deficiency | |||
Recurrent bronchitis | 43 (AI, AP, PI, PP) | 65.1 | Majority |
Idiopathic bronchiectasis | 43 (AI, AP, PI, PP) | 72.1 | Majority |
Recurrent pneumonias* | 43 (AI, AP, PI, PP) | 83.7 | Consensus |
Repeated pneumonia in child | 43 (AI, AP, PI, PP) | 83.7 | Consensus |
Chronic bronchial infection | 43 (AI, AP, PI, PP) | 67.4 | Majority |
Autoinflammatory disease | |||
Recurrent serositis | 43 (AI, AP, PI, PP) | 100.0 | Unanimity |