Serum AGE/RAGEs as potential biomarker in idiopathic pulmonary fibrosis

Respiratory Research

Table 3 ELISA measurements and lung function from IPF patients at 3-year interval

Patient characteristics	Initial	3 yrs.	p-value
sRAGE (pg/ml)	461.53 ± 191.77	375.78 ± 143.25	0.029*
AGEs (μg/ml)	19.07 ± 8.63	17.19 ± 8.45	0.340
Ratio (‰)	52.58 ± 34.58	41.13 ± 14.91	0.079
% FVC	89.21 ± 19.50	79.14 ± 20.63	0.001**
% DLCO	57.84 ± 11.54	48.68 ± 12.73	0.000**
% TLC	87.22 ± 16.89	76.47 ± 15.57	0.000**

Data represent the mean ± SD, AGE advanced glycation end-product, DLCO diffusing capacity for carbon monoxide, FVC forced vital capacity, sRAGE soluble receptor for advanced glycation end-products, TLC Total lung capacity. (*) p-value < 0.05, (**) p-value < 0.01

ISSN: 1465-993X