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Fig. 1 | Respiratory Research

Fig. 1

From: MUC1 deficiency mediates corticosteroid resistance in chronic obstructive pulmonary disease

Fig. 1

MUC1 downregulation and TLR4 overexpression in lung tissue from heavy smokers and COPD patients. Lung tissue from healthy (n = 10), smokers (n = 11) and COPD patients (n = 13) were analysed. MUC1 mRNA gene expression in lung tissue homogenates (a), bronchial epithelial cells (b) and sputum neutrophils (c). d MUC1-CT protein expression in lung homogenates.TLR4 mRNA gene expression in lung tissue homogenates (e), bronchial epithelial cells (f) and sputum neutrophils (g). h MUC1-CT protein expression in lung homogenates. i Correlation of TL4 and MUC1 gene expression in lung tissue from smokers and COPD patients. j Correlation of FEV1% and MUC1 gene expression in lung tissue from smokers and COPD patients. Gene expression was analyzed by real time PCR using the 2-ΔCt as described in methods. Protein expression was analyzed by western blot. Representative western blot are showed. Data are presented as median with interquartile range. “P” exact values were obtained following Kruskal Wallis test. FEV1%: forced expiratory volume in 1 s

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