Table 1 Clinical features
From: MUC1 deficiency mediates corticosteroid resistance in chronic obstructive pulmonary disease
Healthy (n = 15) | Smokers (n = 15) | COPD (n = 22) | |
|---|---|---|---|
Age, yr. (mean (SD) | 66 ± 4 | 65 ± 9 | 67.5 ± 8 |
Sex (M/F) | 11/4 | 12/3 | 17/5 |
Tobacco consumption, pack-yr | 0 | 24.1 ± 6 | 30.5 ± 8 |
FEV1, % pred | 98 ± 3 | 89 ± 6 | 48.6 ± 8* |
FVC, % pred | 91 ± 2 | 90 ± 4 | 91.5 ± 6 |
FEV1/FVC % | 94 ± 5 | 88 ± 1 | 61.2 ± 10* |
GOLD 1 (mild) patients, no. | 0 | 0 | 0 |
GOLD 2 (moderate) patients, no. | 0 | 0 | 3 |
GOLD 3 (severe) patients, no. | 0 | 0 | 19 |
GOLD 4 (very severe) patients, no. | 0 | 0 | 0 |
Receiving inhaled steroids, no. | 0 | 0 | 22 |
Receiving theophyllines, no. | 0 | 0 | 0 |
Receiving long-acting b2-agonist, no. | 0 | 0 | 22 |
Receiving anticholinergics, no. | 0 | 0 | 22 |
Total peripheral blood neutrophils | 4.2 ± 0.6 × 109/L | 6.5 ± 0.9 × 109/L* | 9.5 ± 2.1 × 109/L* |