Fig. 2
From: Role of SOD3 in silica-related lung fibrosis and pulmonary vascular remodeling
Weight loss and right ventricular systolic pressure (RVSP) measurements in mice treated with silica. Deficiency of SOD3 increased body weight loss in early stage of silica-induced lung fibrosis. a Effect of SOD3 gene knockout on body weight loss after intratracheal injection of crystalline silica. Body weight was measured for 28 days. *p < 0.05 for silica-challenged Sod3−/− versus silica-challenged Sod3+/+ mice. b Histochemical analysis of silicotic nodules in the lung of Sod3+/+ and Sod3−/− mice treated with crystalline silica. 40x magnification. c Analysis of collagen specific blue staining. t-test, * < 0.05. d Collagen accumulation in the lung. The results are shown as mean ± SEM, *p < 0.05 when compared to control lung, One Way ANOVA with Holm-Sidak post test