Fig. 2

Cytokine and hyaluronan levels in BAL fluid and lung tissue homogenate. Fluid resuscitation significantly elevated levels of IL-6 from baseline to 12 h in BAL (a) while IL-6 lung homogenate (b) levels were increased 12 h post-saline resuscitation. Levels of IL-8 were also elevated in BAL from baseline to 12 h (c) while there was an increased trend in lung homogenate (d). IL-1β levels significantly increased in both BAL (e) and lung homogenate (f) with fluid resuscitation. Hyaluronan levels increased significantly from baseline to 12 h in BAL (g) both with and without fluid resuscitation. Data are presented as mean ± SEM. n = 8 no fluid resuscitation, n = 8 fluid resuscitation. B = baseline; FR = fluid resuscitation; NFR = no fluid resuscitation *p < 0.05, **p < 0.01, ***p < 0.001