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Table 1 Lung histology scoring system

From: Inflammation and lung injury in an ovine model of fluid resuscitated endotoxemic shock

Score

Vascular features

Extravascular and alveolar involvement

Bronchiole features

0

Minimal

Minimal

None

1

Blood leaking into interstitium; mild RBC obstruction

Mild inflammatory exudate; areas of patchy oedema with some disordered structure

Mild infiltration of inflammatory cells

2

Mild RBC and vascular obstruction; areas of mild and moderate haemorrhage

Moderate inflammatory exudate; areas of moderate alveolar thickening (25–50% visualized lung)

Moderate infiltration of inflammatory cells; detachment of lining in some bronchioles

3

Diffuse haemorrhage; moderate RBC and vascular obstruction

Moderate-severe inflammatory exudate; Severe alveolar thickening (> 50% visualized lung); loss of structure with amorphous material

Complete loss of bronchiole structure; detachment of lining; cellular debris and inflammatory cell exudate

  1. RBC red blood cell