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Table 1 Baseline characteristics of all included subjects

From: Heparin-binding protein in lower airway samples as a biomarker for pneumonia

Variable

Study group

BALF “Pneumonia 2016”

BALF control

BW “Pneumonia 2017”

BW control

Number of subjects

14

14

10

10

Males

8 (57.1)

7 (50.0)

8 (80.0)

4 (40.0)

Age (years)

74 (60.8–82.0)

23.5 (22–24)

66 (58.5–68.8)

55 (39–59)

Current smoker

0 (0.0)

0 (0.0)

2 (20.0)

0 (0.0)

COPD

4 (28.6)

0 (0.0)

3 (30.0)

0 (0.0)

Other pulmonary diseases

1 (7.1)

0 (0.0)

0 (0.0)

0 (0.0)

Diabetes mellitus

4 (28.6)

0 (0.0)

1 (10.0)

1 (10.0)

Cardiovascular disease

5 (35.7)

0 (0.0)

3 (30.0)

2 (20.0)

Non-pulmonary malignancy

5 (35.7)

0 (0.0)

2 (20.0)

0 (0.0)

Radiographic lung infiltrate

11 (78.6)

NA

6 (60.0)

0 (0.0)

Purulent sputum

8 (57.1)

0 (0.0)

3 (30.0)

0 (0.0)

Temp > 38 °C within the last 24 h

12 (85.7)

0 (0.0)

6 (60.0)

0 (0.0)

Days with ventilator

5 (4.0–6.0)

NA

2.5 (1.8–6.5)

0.5 (0–1.0)

Arterial oxygen saturation (%)

93.5 (92.0–94.0)

98 (98.0–99.0)

95.5 (93.3–98.0)

97 (96–98)

Plasma CRP (mg/l)

69.5 (23.5–142.8)

NA

89.5 (53.3–188.0)

3.1 (1.3–10.9)

Blood leukocytes (10^9 cells/l)

10.6 (9.0–15.0)

6.4 (5.4–7.8)

10.3 (7.4–16.7)

6.9 (5.7–8.7)

Blood neutrophils (10^9 cells/l)

9.1 (8.7–13.2)

3.5 (2.7–4.0)

5.7 (5.6–9.9)

3.4 (3.3–5.8)

Gram-positive PPM

5 (35.7)

NA

3 (30.0)

0 (0.0)

Gram-negative PPM

7 (50.0)

NA

6 (60.0)

0 (0.0)

Viral PMM

1 (7.1)

NA

0 (0.0)

0 (0.0)

Fungal PMM

1 (7.1)

NA

0 (0.0)

0 (0.0)

Antibiotic treatment

14 (100.0)

0 (0.0)

10 (100.0)

6 (60.0)

Systemic steroid treatment (= > 10 mg prednisolon)

3 (21.4)

0 (0.0)

2 (20.0)

0 (0.0)

Inhalation steroid treatment

3 (21.4)

0 (0.0)

6 (60.0)

0 (0.0)

Other immunosuppression

1 (7.1)

0 (0.0)

1 (10.0)

0 (0.0)

  1. Data are presented as median (interquartile range) or n (%), unless otherwise stated. BW bronchial wash, BALF bronchoalveolar lavage fluid, COPD chronic obstructive pulmonary disease, CRP C-reactive protein, PPM potentially pathogenic microorganism;