Table 2 Clinically significant exacerbations, by baseline characteristic subgroup

Annualised rate of exacerbations requiring an ED visit/hospitalisation

 Age at asthma onset

  ITT population

0.36 (0.20, 0.67)

468

468

  < 18 years

0.23 (0.08, 0.69)

132

122

  18–< 40 years

0.21 (0.05, 0.83)

173

172

  ≥ 40 years

0.51 (0.19, 1.35)

162

174

 Lung function

  ITT population

0.36 (0.20, 0.67)

468

468

  ≤ 60% predicted FEV₁

0.41 (0.19, 0.86)

245

244

  > 60–80% predicted FEV₁

Non-est*

n/a

n/a

  ≥ 80% predicted FEV₁

Non-est*

n/a

n/a

% patients with no clinically significant exacerbations

 Age at asthma onset

 ITT population

3.03 (2.25, 4.07)

468

468

  < 18 years

2.97 (1.67, 5.26)

132

122

 18–< 40 years

3.19 (1.90, 5.36)

173

172

 ≥ 40 years

3.32 (1.98, 5.55)

162

174

 Lung function

  ITT population

3.03 (2.25, 4.07)

468

468

  ≤ 60% predicted FEV₁

2.67 (1.79, 3.98)

245

244

  > 60–80% predicted FEV₁

3.18 (1.92, 5.28)

177

177

  ≥ 80% predicted FEV₁

4.90 (1.54, 15.62)

46

47