Fig. 1

Experimental protocol to investigate the prophylactic effects of AAT-Fc on elastase-induced airspace enlargement and lung inflammation (A). AAT-Fc or control treatments were administered 1 day prior to PPE instillation and the effects in the lungs were analyzed 1 week later. Cst values (B), representative photomicrographs of lung tissue sections (C), MLI (D), S (E) and numbers of granulocytes in BAL fluid (F) were compared in mice that received saline instillation (saline), vehicle (PBS-PPE), AAT-Fc (AAT-Fc-PPE) or pAAT (pAAT-PPE) treatment prior to PPE. n = 8 in each group. *p < 0.05 vs. PBS-PPE by Tukey–Kramer test, + p < 0.05 vs. pAAT-PPE by Tukey–Kramer test