Table 3 SYRCLE risk of bias table
Study ID | Cassin 1989 | Chen 2018 | Demir 2008 | Jouvencel 2003 | Kertesz 1992 | Park 2011 | Phillips 1995 | Schreiber 1985 | Schreiber 1987 | Xiao-Yan 2020 |
|---|---|---|---|---|---|---|---|---|---|---|
1. Selection bias- Sequence generation | Not applicable There is no control group, i.e. all the animals got antileukotrienes | Unclear risk Not reported | Unclear risk Not reported | Unclear risk Not reported | Unclear risk Not reported | Unclear risk Not reported | Unclear risk Not reported | Not applicable There is no control group, i.e. all the animals got antileukotrienes | Not applicable There is no control group, i.e. all the animals got antileukotrienes | Unclear risk Not reported |
2. Selection bias- Baseline characteristics | Not applicable There is no control group, i.e. all the animals got antileukotrienes | Unclear risk Not reported | Unclear risk Not reported | Unclear risk Not reported | Unclear risk Not reported | Unclear risk Not reported | Unclear risk Not reported | Not applicable There is no control group, i.e. all the animals got antileukotrienes | Not applicable There is no control group, i.e. all the animals got antileukotrienes | Unclear risk Not reported |
3. Selection bias- Allocation concealment | Not applicable There is no control group, i.e. all the animals got antileukotrienes | Unclear risk Not reported | Unclear risk Not reported | Unclear risk Not reported | Unclear risk Not reported | Unclear risk Not reported | Unclear risk Not reported | Not applicable There is no control group, i.e. all the animals got antileukotrienes | Not applicable There is no control group, i.e. all the animals got antileukotrienes | Unclear risk Not reported |
4. Performance bias- Random housing | Not applicable There is no control group, i.e. all the animals got antileukotrienes | Unclear risk Not reported | Unclear risk The different groups were at least raised in the same room, but this does not report enough about the random housing | Unclear risk Not reported | Unclear risk Not reported | Unclear risk Not reported | Unclear risk Not reported | Not applicable There is no control group, i.e. all the animals got antileukotrienes | Not applicable There is no control group, i.e. all the animals got antileukotrienes | Unclear risk Not reported |
5. Performance bias- Blinding | Not applicable There is no control group, i.e. all the animals got antileukotrienes | Unclear risk Not reported | Unclear risk Not reported | Unclear risk Not reported | Unclear risk Not reported | Unclear risk Not reported | Unclear risk Not reported | Not applicable There is no control group, i.e. all the animals got antileukotrienes | Not applicable There is no control group, i.e. all the animals got antileukotrienes | Unclear risk Not reported |
6. Detection bias- Random outcome assessment | Unclear risk Not reported | Unclear risk Not reported | Unclear risk Not reported | Unclear risk Not reported | Unclear risk Random outcome assessment for one outcome; unclear for others | Unclear risk Not reported | Unclear risk Not reported | Unclear risk Not reported | Unclear risk Not reported | Unclear risk Not reported |
7. Detection bias- Blinding | Not applicable There is no control group, i.e. all the animals got antileukotrienes | Unclear risk Not reported | Unclear risk Tissues were prepared in a blinded fashion, although there is no information about blinding all the outcome assessors | Low risk Quote: “All morphometric assessments were made blindly by the same observer (P.J.) (except for the bronchial alveolar attachments, by M.F.) on images of all lung sections” | Unclear risk Not reported | Unclear risk Not reported | Unclear risk Not reported | Not applicable There is no control group, i.e. all the animals got antileukotrienes | Not applicable There is no control group, i.e. all the animals got antileukotrienes | Unclear risk Not reported |
8. Attrition bias- Incomplete outcome data | Unclear risk Unclear if outcome data are reported for all animals | Unclear risk Unclear if outcome data are reported for all animals | Low risk All animals were included in the analysis | Unclear risk Unclear if outcome data are reported for all animals | Unclear risk Unclear if outcome data are reported for all animals | Unclear risk Unclear if outcome data are reported for all animals | Unclear risk Unclear if outcome data are reported for all animals | Unclear risk Unclear if outcome data are reported for all animals | Unclear risk Unclear if outcome data are reported for all animals | High risk Quote "any loss of sample size due to deaths was made up for by random sampling" |
9. Reporting bias- Selective outcome reporting | Unclear risk Protocol not available | Unclear risk Protocol not available | Unclear risk Protocol not available | Unclear risk Protocol not available | Unclear risk Protocol not available | Unclear risk Protocol not available | Unclear risk Protocol not available | Unclear risk Protocol not available | High risk Protocol not available; moreover, the study authors report that data for some outcomes are not shown | Unclear risk Protocol not available |
10. Other- Other sources of bias | Low risk None relevant | Low risk None relevant | Low risk None relevant | Low risk None relevant | Low risk None relevant | Low risk None relevant | Low risk None relevant | Low risk None relevant | Low risk None relevant | Low risk None relevant |