Cheng 2014 | Kim 2015 | Min Kim 2009 | Panjwani 2016 | Rupprecht 2014 | |
---|---|---|---|---|---|
All-cause mortality (initial hospitalization) | 0/6 Mortality seems not to be a prespecified outcome in this study, however no infants died | Not reported | INTERVENTION: 0/15 CONTROL: not reported | 3/13 (2 had an antenatal history of oligohydramnios) | INTERVENTION 1/11 CONTROL 7/11 |
BPD definition (NIH/Jobe / Walsh/unclear) | Treatment study | Jobe INTERVENTION: mild 17/30; mod/severe 13/30 CONTROL: mild 17/36, mod/severe 19/36 | NIH INTERVENTION: mild 4/15 moderate 5/15 severe 6/15 CONTROL: mild 5/15 moderate 3/15 severe 7/15 | Treatment study | Treatment study |
Harms | Not reported | INTERVENTION / CONTROL Infection: 8/3 Gastrointestinal disorders: 5/1 Blood and lymphatic system disorders: 2/1 Cardiac disorders: 1/0 General disorders and administration site conditions: 2/1 Hepatobiliary disorders: 1/0 Pregnancy, puerperium and perinatal conditions: 1/0 Renal and urinary disorders: 2/0 Respiratory, thoracic and mediastinal disorders: 1/1 Vascular disorders: 1/0 Investigations: 4/6 | INTERVENTION/ CONTROL Fever: 0/0 Diarrhea: 1/2 Cough: 0/0 Dermatatis: 0/0 Hypersensitivity reactions: 0/0 Vomiting symptoms: 0/0 t | “ No obvious side effects were noted” | No drugs- associated adverse events were identified; unclear about other adverse events |
Hospital stay | ranging 98–138 days | ||||
All-cause neonatal mortality | 0 | Not reported | Not reported | Not reported | Treatment study, no info about the time of drug administration |
Respiratory support (duration, days) | ranging 7–77 days | Not reported | Not reported | mean ventilation days 41.4 (range 7–69) | INTERVENTION: mechanical ventilation time: mean 41.2 SD 25.3 days CONTROL: mechanical ventilation: 103.7 SD 90.6 days |
Need for mechanical ventilation | Not reported | INTERVENTION: 7/37 at 2 weeks CONTROL: 7/40 at two weeks | INTERVENTION: before intervention: 11/15 after 2 weeks of montelukast 7 CONTROL: before intervention: 11; after 2 weeks of montelukast 8 | Not reported | Not reported |
Major neurodevelop-mental disability | Mental developmental index at two years old: ranging 76–108 PDI at two years old: ranging 96–114 | ||||
Retinopathy of prematurity | 1 | Not reported | Not reported | 8 | Not reported |