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Table 4 Proteins significantly altered in both current and former smokers as compared to never smokers

From: Smoking induces sex-specific changes in the small airway proteome

Protein

Current smokers vs never smokers

Former smokers vs never smokers

p-value

q-value

log2(fold change)

p-value

q-value

log2(fold change)

Complement decay-accelerating factor

7.52E−05

0.002

 − 0.64

4.63E−02

0.310

 − 0.34

Macrophage mannose receptor 1

2.24E−02

0.084

 − 0.40

2.03E−02

0.221

 − 0.40

Interleukin-1 receptor-like 1

6.67E−03

0.039

 − 0.36

2.68E−03

0.136

 − 0.36

Adenylate kinase isoenzyme 1

4.43E−02

0.115

 − 0.27

3.37E−02

0.260

 − 0.20

Small ubiquitin-related modifier 3

4.01E−02

0.109

0.24

4.48E−02

0.310

 − 0.18

Macrophage-capping protein

2.79E−02

0.092

0.33

3.23E−02

0.260

 − 0.22

Peptidyl-prolyl cis–trans isomerase A

4.93E−02

0.124

0.36

5.95E−03

0.147

 − 0.45

C-X-C motif chemokine 16

3.41E−02

0.096

0.37

1.34E−02

0.194

 − 0.54

Cofilin-1

1.51E−02

0.061

0.38

1.21E−02

0.190

 − 0.29

Gelsolin

1.46E−02

0.061

0.39

1.02E−02

0.189

 − 0.32

Fructose-bisphosphate aldolase A

2.19E−02

0.084

0.43

2.30E−02

0.225

 − 0.30

Ras-related C3 botulinum toxin substrate 1

2.33E−03

0.020

0.44

1.95E−03

0.136

 − 0.25

14–3-3 protein zeta/delta

8.97E−03

0.047

0.44

2.96E−02

0.253

 − 0.29

14–3-3 protein beta/alpha

7.38E−03

0.041

0.46

1.83E−02

0.221

 − 0.27

6-phosphogluconate dehydrogenase, decarboxylating

1.13E−02

0.051

0.51

6.49E−03

0.147

 − 0.38

Heat shock protein HSP 90-alpha/beta

1.97E−03

0.019

0.58

4.73E−02

0.310

 − 0.22

  1. Data presented is based on the t-test adjusted for age and the investigator