High concentration delivery | Low concentration delivery | p | |
---|---|---|---|
No. of patients | 84 | 80 | |
Age (years) | 56.0 (44.3, 65.8) | 55 (44.5, 68.8) | 0.920 |
Male, % | 35 (42%) | 36 (45%) | 0.753 |
Ethnicity, % | 0.268 | ||
Caucasian | 29 (35%) | 36 (45%) | |
African American | 37 (44%) | 31 (39%) | |
Hispanic | 15 (18%) | 10 (13%) | |
Asian | 0 | 2 (3%) | |
Other | 3 (4%) | 2 (1%) | |
Indication to use iEPO, % | |||
Hypoxemia | 58 (69%) | 56 (70%) | 1.0 |
Pulmonary hypertension | 30 (36%) | 25 (31%) | 0.620 |
Right heart failure | 20 (24%) | 14 (18%) | 0.342 |
No. of patients had positive response to iEPO, % | |||
No. of patients had mPAP reduction ≥ 10% | 46% (10/22) | 47% (7/15) | 1.0 |
No. of patients had SpO2/FIO2 increment ≥ 10% | 43% (25/58) | 38% (21/56) | 0.572 |
No. of patients had SpO2/FIO2 increment ≥ 20% | 26% (15/58) | 18% (10/56) | 0.368 |
No. of patients had PaO2/FIO2 increment ≥ 10% | 76% (34/45) | 80% (28/35) | 0.789 |
No. of patients had PaO2/FIO2 increment ≥ 20% | 69% (31/45) | 63% (22/35) | 0.637 |
iEPO duration, hours | 42.0 (17.9, 94.6) | 48.1 (18.1, 85.8) | 0.868 |
iEPO weaning for survived patients | 53 | 45 | |
Followed all steps to wean, % | 96% (51/53) | 71% (32/45) | < 0.001 |
Extubated to iEPO via HFNC, % | 17% (9/53) | 2% (1/45) | 0.038 |
Total number of syringes administered per patient | 5 (3, 10) | 12 (6, 22) | 0.001 |
Duration of invasive ventilation, days | 6 (3, 12) | 9 (5, 18) | 0.028 |
ICU length of stay, days | 16 (8.3, 28) | 15 (7.0, 30) | 0.840 |
ECMO, % | 10 (12%) | 10 (13%) | 1.0 |
Mortality, % | 31 (37%) | 35 (44%) | 0.427 |