Fig. 3From: Inhibition of fatty acid synthase protects obese mice from acute lung injury via ameliorating lung endothelial dysfunctionFASN regulated the levels of mitochondrial ROS in MLECs under metabolic stress in response to LPS. a–f Representative western blots of Mfn2, p-Drp1 and Drp1 (a, d), and corresponding quantitative analysis of Mfn2 (b, e) and p-Drp1/Drp (c, f) in each group of MLECs. n = 3 biologically independent experiments. One-way ANOVA and LSD or Games–Howell posthoc analysis. g–j Representative immunofluorescence images (g), flow cytometry analysis (h) and quantitative analysis (i, j) of mitoSOX in each group of MLECs. n = 3 biologically independent experiments. Scale bar: 100 μm. One-way ANOVA and Games–Howell posthoc analysis. k FASN activity were detected in MLECs under PA in response to LPS with or without C75 treatment. One-way ANOVA and LSD posthoc analysis. n = 3 biologically independent experiments. Data were represented as mean ± SDBack to article page