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  1. Lung epithelial Na+ channels (ENaC) are regulated by cell Ca2+ signal, which may contribute to calcium antagonist-induced noncardiogenic lung edema. Although K+ channel modulators regulate ENaC activity in normal...

    Authors: Dong-Yun Han, Hong-Guang Nie, Xiu Gu, Ramesh C Nayak, Xue-Feng Su, Jian Fu, Yongchang Chang, Vijay Rao and Hong-Long Ji
    Citation: Respiratory Research 2010 11:65
  2. Elevated circulating levels of several inflammatory biomarkers have been described in selected patient populations with COPD, although less is known about their population-based distribution. The aims of this ...

    Authors: Francisco Garcia-Rio, Marc Miravitlles, Joan B Soriano, Luis Muñoz, Enric Duran-Tauleria, Guadalupe Sánchez, Víctor Sobradillo and Julio Ancochea
    Citation: Respiratory Research 2010 11:63
  3. Previous observations demonstrate that Cftr-null cells and tissues exhibit alterations in cholesterol processing including perinuclear cholesterol accumulation, increased de novo synthesis, and an increase in pla...

    Authors: Danjun Fang, Richard H West, Mary E Manson, Jennifer Ruddy, Dechen Jiang, Stephen F Previs, Nitin D Sonawane, James D Burgess and Thomas J Kelley
    Citation: Respiratory Research 2010 11:61
  4. Multidrug resistance-associated protein-1 (MRP1) protects against oxidative stress and toxic compounds generated by cigarette smoking, which is the main risk factor for chronic obstructive pulmonary disease (C...

    Authors: Simona E Budulac, Dirkje S Postma, Pieter S Hiemstra, Lisette IZ Kunz, Mateusz Siedlinski, Henriette A Smit, Judith M Vonk, Bea Rutgers, Wim Timens and H Marike Boezen
    Citation: Respiratory Research 2010 11:60
  5. Bacterial colonisation in chronic obstructive pulmonary disease (COPD) contributes to airway inflammation and modulates exacerbations. We assessed risk factors for bacterial colonisation in COPD.

    Authors: Marc Miravitlles, Alicia Marín, Eduard Monsó, Sara Vilà, Cristian de la Roza, Ramona Hervás, Cristina Esquinas, Marian García, Laura Millares, Josep Morera and Antoni Torres
    Citation: Respiratory Research 2010 11:58
  6. Angiotensin converting enzyme (ACE) gene contains a polymorphism, consisting of either the presence (I) or absence (D) of a 287 base pair fragment. Deletion (D) is associated with increased circulating ACE (cA...

    Authors: Gabriel Dimitriou, Despina Papakonstantinou, Eleana F Stavrou, Sotirios Tzifas, Aggeliki Vervenioti, Anny Onufriou, Aglaia Athanassiadou and Stefanos Mantagos
    Citation: Respiratory Research 2010 11:57
  7. Chronic obstructive pulmonary disease (COPD) is the 4th leading cause of mortality worldwide. Long-acting bronchodilators are considered first line therapies for patients with COPD but their effects on mortality ...

    Authors: Agnes Kliber, Larry D Lynd and Don D Sin
    Citation: Respiratory Research 2010 11:56
  8. Airway remodeling in COPD includes reorganization of the extracellular matrix. Proteoglycans play a crucial role in this process as regulators of the integrity of the extracellular matrix. Altered proteoglycan...

    Authors: Oskar Hallgren, Kristian Nihlberg, Magnus Dahlbäck, Leif Bjermer, Leif T Eriksson, Jonas S Erjefält, Claes-Göran Löfdahl and Gunilla Westergren-Thorsson
    Citation: Respiratory Research 2010 11:55
  9. It is widely assumed that apoptosis of eosinophils is a central component of resolution of allergic airway disease. However, this has not been demonstrated in human allergic airways in vivo. Based on animal in...

    Authors: Lena Uller, Cecilia Ahlström Emanuelsson, Morgan Andersson, Jonas S Erjefält, Lennart Greiff and Carl G Persson
    Citation: Respiratory Research 2010 11:54
  10. Perfluorocarbons (PFC) are used to improve gas exchange in diseased lungs. PFC have been shown to affect various cell types. Thus, effects on alveolar type II (ATII) cells and surfactant metabolism can be expe...

    Authors: Andreas Wemhöner, Irmgard Hackspiel, Nina Hobi, Andrea Ravasio, Thomas Haller and Mario Rüdiger
    Citation: Respiratory Research 2010 11:52
  11. The dust mite Blomia tropicalis is an important source of aeroallergens in tropical areas. Although a mouse model for B. tropicalis extract (BtE)-induced asthma has been described, no study comparing different mo...

    Authors: Tiana Baqueiro, Momtchilo Russo, Virgínia MG Silva, Thayna Meirelles, Pablo RS Oliveira, Eliane Gomes, Renato Barboza, Ana T Cerqueira-Lima, Camila A Figueiredo, Lain Pontes-de-Carvalho and Neuza M Alcântara-Neves
    Citation: Respiratory Research 2010 11:51
  12. The non-invasive assessment of airway inflammation is potentially advantageous in asthma management. Exhaled carbon monoxide (eCO) measurement is cheap and has been proposed to reflect airway inflammation and ...

    Authors: Jingying Zhang, Xin Yao, Rongbin Yu, Jianling Bai, Yun Sun, Mao Huang, Ian M Adcock and Peter J Barnes
    Citation: Respiratory Research 2010 11:50
  13. Lungs of cystic fibrosis (CF) patients are chronically infected with Pseudomonas aeruginosa. Increased airway constriction has been reported in CF patients but underplaying mechanisms have not been elucidated. Ai...

    Authors: Yong-Zheng Wu, Mohammad Abolhassani, Mario Ollero, Fariel Dif, Naonori Uozumi, Micheline Lagranderie, Takao Shimizu, Michel Chignard and Lhousseine Touqui
    Citation: Respiratory Research 2010 11:49
  14. A major feature of chronic obstructive pulmonary disease (COPD) is airway remodelling, which includes an increased airway smooth muscle (ASM) mass. The mechanisms underlying ASM remodelling in COPD are current...

    Authors: Tonio Pera, Reinoud Gosens, Andries H Lesterhuis, Riham Sami, Marco van der Toorn, Johan Zaagsma and Herman Meurs
    Citation: Respiratory Research 2010 11:48
  15. The exhaled nitric oxide (eNO) signal is a marker of inflammation, and can be partitioned into proximal [J'awNO (nl/s), maximum airway flux] and distal contributions [CANO (ppb), distal airway/alveolar NO concent...

    Authors: James L Puckett, Richard WE Taylor, Szu-Yun Leu, Olga L Guijon, Anna S Aledia, Stanley P Galant and Steven C George
    Citation: Respiratory Research 2010 11:47
  16. Abnormal apoptotic events in chronic obstructive pulmonary disease (COPD) subvert cellular homeostasis and may play a primary role in its pathogenesis. However, studies in human subjects are limited.

    Authors: Marianna Siganaki, Anastasios V Koutsopoulos, Eirini Neofytou, Eleni Vlachaki, Maria Psarrou, Nikolaos Soulitzis, Nikolaos Pentilas, Sophia Schiza, Nikolaos M Siafakas and Eleni G Tzortzaki
    Citation: Respiratory Research 2010 11:46
  17. Abnormal immune responses are believed to be highly relevant in the pathogenesis of chronic obstructive pulmonary disease (COPD). Dendritic cells provide a critical checkpoint for immunity by their capacity to...

    Authors: Robert Vassallo, Paula R Walters, Jeffrey Lamont, Theodore J Kottom, Eunhee S Yi and Andrew H Limper
    Citation: Respiratory Research 2010 11:45
  18. Previous studies of the natural history of alpha-1-antitrypsin (AAT) deficiency are mostly based on highly selected patients. The aim of this study was to analyse the mortality of PiZZ individuals.

    Authors: Hanan A Tanash, Peter M Nilsson, Jan-Ã…ke Nilsson and Eeva Piitulainen
    Citation: Respiratory Research 2010 11:44
  19. Exhaled nitric oxide is a non-invasive marker of airway inflammation and a portable analyser, the NIOX MINO (Aerocrine AB, Solna, Sweden), is now available. This study aimed to assess the reproducibility of th...

    Authors: Anna Selby, Bernie Clayton, Jane Grundy, Katy Pike, Kirsty Drew, Abid Raza, Ramesh Kurukulaaratchy, S Hasan Arshad and Graham Roberts
    Citation: Respiratory Research 2010 11:43
  20. We analyzed serial concentrations of multiple inflammatory mediators from serum and induced sputum obtained from patients with stable COPD and controls. The objective was to determine which proteins could be u...

    Authors: Shawn D Aaron, Katherine L Vandemheen, Timothy Ramsay, Chun Zhang, Zafrira Avnur, Tania Nikolcheva and Anthony Quinn
    Citation: Respiratory Research 2010 11:41
  21. Little is known about the influencing potential of specific characteristics on lung function in different populations. The aim of this analysis was to determine whether lung function determinants differ betwee...

    Authors: Eva Schnabel, Chih-Mei Chen, Beate Koch, Stefan Karrasch, Rudolf A Jörres, Torsten Schäfer, Claus Vogelmeier, Ralf Ewert, Christoph Schäper, Henry Völzke, Anne Obst, Stephan B Felix, H-Erich Wichmann, Sven Gläser and Joachim Heinrich
    Citation: Respiratory Research 2010 11:40
  22. Basic and clinical studies suggest that hypothalamic-pituitary-adrenal (HPA) axis is the neuroendocrine-immnue pathway that functionally regulates the chronic inflammatory disease including asthma. Our previou...

    Authors: Shui-Juan Zhang, Yang-Mei Deng, Yi-Liang Zhu, Xin-Wei Dong, Jun-Xia Jiang and Qiang-Min Xie
    Citation: Respiratory Research 2010 11:39
  23. Baroreflex allows to reduce sudden rises or falls of arterial pressure through parallel RR interval fluctuations induced by autonomic nervous system. During spontaneous breathing, the application of positive e...

    Authors: Andry Van de Louw, Claire Médigue, Yves Papelier and François Cottin
    Citation: Respiratory Research 2010 11:38
  24. Early diagnosis of pulmonary hypertension (PH) in idiopathic pulmonary fibrosis (IPF) has potential prognostic and therapeutic implications but can be difficult due to the lack of specific clinical manifestati...

    Authors: Kyung-Hee Kim, Fabien Maldonado, Jay H Ryu, Patrick W Eiken, Thomas E Hartman, Brian J Bartholmai, Paul A Decker and Eunhee S Yi
    Citation: Respiratory Research 2010 11:37
  25. Cigarette smoking is an important risk factor for pulmonary arterial hypertension (PAH) in chronic obstructive pulmonary disease (COPD). Chymase has been shown to function in the enzymatic production of angiot...

    Authors: Tao Wang, Su-Xia Han, Shang-Fu Zhang, Yun-Ye Ning, Lei Chen, Ya-Juan Chen, Guang-Ming He, Dan Xu, Jin An, Ting Yang, Xiao-Hong Zhang and Fu-Qiang Wen
    Citation: Respiratory Research 2010 11:36
  26. Dendritic cells (DC) linking innate and adaptive immune responses are present in human lungs, but the characterization of different subsets and their role in COPD pathogenesis remain to be elucidated. The aim ...

    Authors: Geert R Van Pottelberge, Ken R Bracke, Ingel K Demedts, Kim De Rijck, Susanne M Reinartz, Cornelis M van Drunen, Geert M Verleden, Frank E Vermassen, Guy F Joos and Guy G Brusselle
    Citation: Respiratory Research 2010 11:35
  27. Metabolites of arachidonic acid such as prostacyclin (PGI2) have been shown to participate in the pathogenesis of pulmonary fibrosis by inhibiting the expression of pro-inflammatory and pro-fibrotic mediators. In...

    Authors: Yuanjue Zhu, Yong Liu, Weixun Zhou, Ruolan Xiang, Lei Jiang, Kewu Huang, Yu Xiao, Zijian Guo and Jinming Gao
    Citation: Respiratory Research 2010 11:34
  28. Histone deacetylase (HDAC) inhibitors, developed as promising anti-tumor drugs, exhibit their anti-inflammatory properties due to their effects on reduction of inflammatory cytokines.

    Authors: Yun-Feng Ni, Jian Wang, Xiao-Long Yan, Feng Tian, Jin-Bo Zhao, Yun-Jie Wang and Tao Jiang
    Citation: Respiratory Research 2010 11:33
  29. Inflammatory lung diseases are a major morbidity factor in children. Therefore, novel strategies for early detection of inflammatory lung diseases are of high interest. Bacterial lipopolysaccharide (LPS) is re...

    Authors: Veronica Marcos, Phillip Latzin, Andreas Hector, Sebastian Sonanini, Florian Hoffmann, Martin Lacher, Barbara Koller, Philip Bufler, Thomas Nicolai, Dominik Hartl and Matthias Griese
    Citation: Respiratory Research 2010 11:32
  30. Pulmonary fibrosis is a progressive and lethal disorder. Although the precise mechanisms of pulmonary fibrosis are not fully understood, oxidant/antioxidant and Th1/Th2 balances may play an important role in m...

    Authors: Norihiro Kikuchi, Yukio Ishii, Yuko Morishima, Yuichi Yageta, Norihiro Haraguchi, Ken Itoh, Masayuki Yamamoto and Nobuyuki Hizawa
    Citation: Respiratory Research 2010 11:31
  31. Numerous studies have demonstrated associations between genetic markers and COPD, but results have been inconsistent. One reason may be heterogeneity in disease definition. Unsupervised learning approaches may...

    Authors: Michael H Cho, George R Washko, Thomas J Hoffmann, Gerard J Criner, Eric A Hoffman, Fernando J Martinez, Nan Laird, John J Reilly and Edwin K Silverman
    Citation: Respiratory Research 2010 11:30
  32. Anxiety in patients with chronic obstructive pulmonary disease (COPD) is associated with self-reported disability. The purpose of this study is to determine whether there is an association between anxiety and ...

    Authors: Nicholas D Giardino, Jeffrey L Curtis, Adin-Cristian Andrei, Vincent S Fan, Joshua O Benditt, Mark Lyubkin, Keith Naunheim, Gerard Criner, Barry Make, Robert A Wise, Susan K Murray, Alfred P Fishman, Frank C Sciurba, Israel Liberzon and Fernando J Martinez
    Citation: Respiratory Research 2010 11:29
  33. Asthma is a chronic inflammatory disease of the airway that is characterized by a Th2-type of immune response with increasing evidence for involvement of Th17 cells. The role of IL-6 in promoting effector T ce...

    Authors: Wendy A Neveu, Jenna L Allard, Danielle M Raymond, Lorraine M Bourassa, Stephanie M Burns, Janice Y Bunn, Charles G Irvin, David A Kaminsky and Mercedes Rincon
    Citation: Respiratory Research 2010 11:28
  34. Previous experimental studies have shown that injurious mechanical ventilation has a direct effect on pulmonary and systemic immune responses. How these responses are propagated or attenuated is a matter of sp...

    Authors: Jesús Villar, Nuria E Cabrera, Milena Casula, Carlos Flores, Francisco Valladares, Lucio Díaz-Flores, Mercedes Muros, Arthur S Slutsky and Robert M Kacmarek
    Citation: Respiratory Research 2010 11:27
  35. GSK256066 is a selective phosphodiesterase 4 inhibitor that can be given by inhalation, minimising the potential for side effects. We evaluated the effects of GSK256066 on airway responses to allergen challeng...

    Authors: Dave Singh, Frank Petavy, Alex J Macdonald, Aili L Lazaar and Brian J O'Connor
    Citation: Respiratory Research 2010 11:26
  36. A strong genetic influence by the MHC class II region has been reported in sarcoidosis, however in many studies with different results. This may possibly be caused by actual differences between distinct ethnic...

    Authors: Johan Grunewald, Boel Brynedal, Pernilla Darlington, Magnus Nisell, Kerstin Cederlund, Jan Hillert and Anders Eklund
    Citation: Respiratory Research 2010 11:25
  37. Lung cancer often develops in association with chronic pulmonary inflammatory diseases with an influx of neutrophils. More detailed information on inflammatory pathways and the role of neutrophils herein is a ...

    Authors: Nejla Güngör, Jeroen LA Pennings, Ad M Knaapen, Roland K Chiu, Marco Peluso, Roger WL Godschalk and Frederik J Van Schooten
    Citation: Respiratory Research 2010 11:24
  38. Atopic and non-atopic wheezing may be caused by different etiologies: while eosinophils are more important in atopic asthmatic wheezers, neutrophils are predominantly found in BAL samples of young children wit...

    Authors: Leonardo A Pinto, Martin Depner, Norman Klopp, Thomas Illig, Christian Vogelberg, Erika von Mutius and Michael Kabesch
    Citation: Respiratory Research 2010 11:23
  39. The relationship between airway structural changes (remodeling) and airways hyperresponsiveness (AHR) is unclear. Asthma guidelines suggest treating persistent asthma with inhaled corticosteroids and long acti...

    Authors: Erik P Riesenfeld, Michael J Sullivan, John A Thompson-Figueroa, Hans C Haverkamp, Lennart K Lundblad, Jason HT Bates and Charles G Irvin
    Citation: Respiratory Research 2010 11:22
  40. Transforming growth factor β1 (TGF-β1)-mediated epithelial mesenchymal transition (EMT) of alveolar epithelial cells (AEC) may contribute to lung fibrosis. Since PPARγ ligands have been shown to inhibit fibrob...

    Authors: Xiahui Tan, Hayat Dagher, Craig A Hutton and Jane E Bourke
    Citation: Respiratory Research 2010 11:21
  41. Vanadium pentoxide (V2O5) exposure is a cause of occupational bronchitis and airway fibrosis. Respiratory syncytial virus (RSV) is a ubiquitous pathogen that causes airway inflammation. It is unknown whether indi...

    Authors: Elizabeth A Turpin, Aurita Antao-Menezes, Mark F Cesta, James B Mangum, Duncan G Wallace, Edilberto Bermudez and James C Bonner
    Citation: Respiratory Research 2010 11:20
  42. Liver × receptor α (LXRα) and β (LXRβ) are members of the nuclear receptor super family of ligand-activated transcription factors, a super family which includes the perhaps better known glucocorticoid receptor...

    Authors: Concetta Crisafulli, Emanuela Mazzon, Irene Paterniti, Maria Galuppo, Placido Bramanti and Salvatore Cuzzocrea
    Citation: Respiratory Research 2010 11:19
  43. Lung cancer is a very frequent and lethal tumor with an identifiable risk population. Cytological analysis and chest X-ray failed to reduce mortality, and CT screenings are still controversially discussed. Rec...

    Authors: Petra Leidinger, Andreas Keller, Sabrina Heisel, Nicole Ludwig, Stefanie Rheinheimer, Veronika Klein, Claudia Andres, Andrea Staratschek-Jox, Jürgen Wolf, Erich Stoelben, Bernhard Stephan, Ingo Stehle, Jürg Hamacher, Hanno Huwer, Hans-Peter Lenhof and Eckart Meese
    Citation: Respiratory Research 2010 11:18
  44. The CC-chemokine receptor-3 (CCR3) has emerged as a target molecule for pharmacological intervention in allergic inflammation.

    Authors: Lennart Greiff, Cecilia Ahlström-Emanuelsson, Ash Bahl, Thomas Bengtsson, Kerstin Dahlström, Jonas Erjefält, Henrik Widegren and Morgan Andersson
    Citation: Respiratory Research 2010 11:17
  45. No effective treatment for acute lung injury and fibrosis currently exists. Aim of this study was to investigate the time-dependent effect of bone marrow-derived mesenchymal stem cells (BMDMSCs) on bleomycin (...

    Authors: Shin-Hwa Lee, An-Soo Jang, Young-Eun Kim, Ji-Yeon Cha, Tae-Hoon Kim, Seok Jung, Seong-Kyu Park, You-Kyoung Lee, Jong-Ho Won, Yong-Hoon Kim and Choon-Sik Park
    Citation: Respiratory Research 2010 11:16

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