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  1. Early-life respiratory viral infections, notably with respiratory syncytial virus (RSV), increase the risk of subsequent development of childhood asthma. The purpose of this study was to assess whether early-l...

    Authors: Jessica S Siegle, Nicole Hansbro, Cristan Herbert, Helene F Rosenberg, Joseph B Domachowske, Kelly L Asquith, Paul S Foster and Rakesh K Kumar
    Citation: Respiratory Research 2010 11:14
  2. Nicotine plays an important role in cigarette-smoke-associated airway disease. The present study was designed to examine if nicotine could induce airway hyperresponsiveness through kinin receptors, and if so, ...

    Authors: Yuan Xu, Yaping Zhang and Lars-Olaf Cardell
    Citation: Respiratory Research 2010 11:13
  3. Although studies show that maternal smoking during pregnancy increases the risks of respiratory outcomes in childhood, evidence concerning the effects of household environmental tobacco smoke (ETS) exposure re...

    Authors: Ching-Hui Tsai, Jiun-Hau Huang, Bing-Fang Hwang and Yungling L Lee
    Citation: Respiratory Research 2010 11:11
  4. Acute exacerbations contribute to the morbidity and mortality associated with chronic obstructive pulmonary disease (COPD). This proof-of-concept study evaluates whether intermittent pulsed moxifloxacin treatm...

    Authors: Sanjay Sethi, Paul W Jones, Marlize Schmitt Theron, Marc Miravitlles, Ethan Rubinstein, Jadwiga A Wedzicha and Robert Wilson
    Citation: Respiratory Research 2010 11:10

    The Correction to this article has been published in Respiratory Research 2010 11:88

  5. Previous histological and imaging studies have shown the presence of variability in the degree of bronchoconstriction of airways sampled at different locations in the lung (i.e., heterogeneity). Heterogeneity ...

    Authors: Peter B Noble, Robert A McLaughlin, Adrian R West, Sven Becker, Julian J Armstrong, Peter K McFawn, Peter R Eastwood, David R Hillman, David D Sampson and Howard W Mitchell
    Citation: Respiratory Research 2010 11:9
  6. The International Study of Asthma and Allergies in Childhood (ISAAC) Phase One showed large worldwide variations in the prevalence of symptoms of asthma, rhinoconjunctivitis and eczema, up to 10 to 20 fold bet...

    Authors: M Innes Asher, Alistair W Stewart, Javier Mallol, Stephen Montefort, Christopher KW Lai, Nadia Aït-Khaled and Joseph Odhiambo
    Citation: Respiratory Research 2010 11:8
  7. Air pollutant exposure has been linked to a rise in wheezing illnesses. Clinical data highlight that exposure to mainstream tobacco smoke (MS) and environmental tobacco smoke (ETS) as well as exposure to diese...

    Authors: Tania Maes, Sharen Provoost, Ellen A Lanckacker, Didier D Cataldo, Jeroen AJ Vanoirbeek, Benoit Nemery, Kurt G Tournoy and Guy F Joos
    Citation: Respiratory Research 2010 11:7
  8. Staphylococcus aureus releases virulence factors (VF) that may impair the innate protective functions of airway cells. The aim of this study was to determine whether a long-acting β2 adrenergic receptor agonist (...

    Authors: Jean-Marie Zahm, Franck Delavoie, Férial Toumi, Béatrice Nawrocki-Raby, Claire Kileztky, Jean Michel, Gérard Balossier, Malcolm Johnson, Christelle Coraux and Philippe Birembaut
    Citation: Respiratory Research 2010 11:6
  9. The discrepancy between functional and inflammatory airway response to ozone has been reported in normal subjects, but few data are available for stable asthmatics regularly treated with inhaled corticosteroids.

    Authors: Barbara Vagaggini, Maria Laura E Bartoli, Silvana Cianchetti, Francesco Costa, Elena Bacci, Federico L Dente, Antonella Di Franco, Laura Malagrinò and Pierluigi Paggiaro
    Citation: Respiratory Research 2010 11:5
  10. Burkholderia cenocepacia, an opportunistic pathogen that causes lung infections in cystic fibrosis (CF) patients, is associated with rapid and usually fatal lung deterioration due to necrotizing pneumonia and sep...

    Authors: Luiz G Cunha Jr, Maria-Cristina Assis, Gloria-Beatriz Machado, Ana P Assef, Elizabeth A Marques, Robson S Leão, Alessandra M Saliba and Maria-Cristina Plotkowski
    Citation: Respiratory Research 2010 11:4
  11. Cognitive impairment is one of the main consequences of obstructive sleep apnea (OSA) and is usually attributed in part to the oxidative stress caused by intermittent hypoxia in cerebral tissues. The presence ...

    Authors: Isaac Almendros, Josep M Montserrat, Marta Torres, Constancio González, Daniel Navajas and Ramon Farré
    Citation: Respiratory Research 2010 11:3
  12. Toll-like receptors (TLRs) are critical components in the regulation of pulmonary immune responses and the recognition of respiratory pathogens such as Mycobacterium Tuberculosis (M.tb). Through examination of hu...

    Authors: Esmeralda Juarez, Carlos Nuñez, Eduardo Sada, Jerrold J Ellner, Stephan K Schwander and Martha Torres
    Citation: Respiratory Research 2010 11:2
  13. The purpose of this study was to evaluate collagen deposition, mRNA collagen synthesis and TGF-beta expression in the lung tissue in an experimental model of scleroderma after collagen V-induced nasal tolerance.

    Authors: Ana Paula P Velosa, Walcy R Teodoro, Daniel M dos Anjos, Renata Konno, Cristiane C Oliveira, Maria LH Katayama, Edwin R Parra, Vera L Capelozzi and Natalino H Yoshinari
    Citation: Respiratory Research 2010 11:1
  14. In idiopathic pulmonary arterial hypertension (IPAH), peripheral airway obstruction is frequent. This is partially attributed to the mediator dysbalance, particularly an excess of endothelin-1 (ET-1), to incre...

    Authors: Annette S Droste, David Rohde, Mirko Voelkers, Arthur Filusch, Thomas Bruckner, Mathias M Borst, Hugo A Katus and F Joachim Meyer
    Citation: Respiratory Research 2009 10:129
  15. Urokinase (UK) 2 200 U/kg·h for 12 hours infusion(UK-12 h)is an ACCP recommended regimen in treating acute pulmonary embolism (PE). It is unclear whether this dose and time can be reduced further. We compared ...

    Authors: Chen Wang, Zhenguo Zhai, Yuanhua Yang, Yadong Yuan, Zhaozhong Cheng, Lirong Liang, Huaping Dai, Kewu Huang, Weixuan Lu, Zhonghe Zhang, Xiansheng Cheng and Ying H Shen
    Citation: Respiratory Research 2009 10:128
  16. Lungs are exposed to the outside environment and therefore to toxic and infectious agents or allergens. This may lead to permanent activation of innate immune response elements. A Disintegrin And Metalloproteinas...

    Authors: Genevieve Paulissen, Natacha Rocks, Maud M Gueders, Celine Crahay, Florence Quesada-Calvo, Sandrine Bekaert, Jonathan Hacha, Mehdi El Hour, Jean-Michel Foidart, Agnes Noel and Didier D Cataldo
    Citation: Respiratory Research 2009 10:127
  17. Toll-like receptor 4 (TLR4) is essential in lipopolysaccharide (LPS)-induced fibroblast activation and collagen secretion in vitro. However, its effects on the process of lung fibroblast activation and fibrosi...

    Authors: ZhengYu He, YeSen Zhu and Hong Jiang
    Citation: Respiratory Research 2009 10:126
  18. Low socioeconomic status (SES) has been linked to higher morbidity in patients with chronic diseases, but may be particularly relevant to asthma, as asthmatics of lower SES may have higher exposures to indoor ...

    Authors: Simon L Bacon, Anne Bouchard, Eric B Loucks and Kim L Lavoie
    Citation: Respiratory Research 2009 10:125
  19. Initiation of ventilation using high tidal volumes in preterm lambs causes lung injury and inflammation. Antenatal corticosteroids mature the lungs of preterm infants and postnatal corticosteroids are used to ...

    Authors: Noah H Hillman, J Jane Pillow, Molly K Ball, Graeme R Polglase, Suhas G Kallapur and Alan H Jobe
    Citation: Respiratory Research 2009 10:124
  20. Sildenafil, a potent phosphodiesterase type 5 (PDE5) inhibitor, has been proposed as a treatment for pulmonary arterial hypertension (PAH). The mechanism of its anti-proliferative effect on pulmonary artery sm...

    Authors: Cong Wang, Ji-Feng Li, Lan Zhao, Jie Liu, Jun Wan, Yue Xiu Wang, Jun Wang and Chen Wang
    Citation: Respiratory Research 2009 10:123
  21. Air pollutant exposure has been associated with an increase in inflammatory markers and a decline in lung function in asthmatic children. Several studies suggest that dietary intake of fruits and vegetables mi...

    Authors: Isabelle Romieu, Albino Barraza-Villarreal, Consuelo Escamilla-Núñez, Jose L Texcalac-Sangrador, Leticia Hernandez-Cadena, David Díaz-Sánchez, Jordi De Batlle and Blanca E Del Rio-Navarro
    Citation: Respiratory Research 2009 10:122
  22. The adherence to long tuberculosis (TB) treatment is a key factor in TB control programs. Always some patients abandon the treatment or die. The objective of this study is to identify factors associated with d...

    Authors: Joan A Caylà, Teresa Rodrigo, Juan Ruiz-Manzano, José A Caminero, Rafael Vidal, José M García, Rafael Blanquer and Martí Casals
    Citation: Respiratory Research 2009 10:121
  23. Secondhand smoke (SHS) exposure is an independent risk factor for asthma, rhinosinusitis, and more severe respiratory tract infections in children and adults. Impaired mucociliary clearance with subsequent muc...

    Authors: Amy N Savitski, Clementina Mesaros, Ian A Blair, Noam A Cohen and James L Kreindler
    Citation: Respiratory Research 2009 10:120
  24. Platelet-derived growth factor A (PDGF-A) signals solely through PDGF-Rα, and is required for fibroblast proliferation and transdifferentiation (fibroblast to myofibroblast conversion) during alveolar developm...

    Authors: Patricia W Kimani, Amey J Holmes, Ruth E Grossmann and Stephen E McGowan
    Citation: Respiratory Research 2009 10:119
  25. Continuous exposure to tobacco smoke (TS) is a key cause of chronic obstructive pulmonary disease (COPD), a complex multifactorial disease that is difficult to model in rodents. The spontaneously hypertensive ...

    Authors: Sarah J Bolton, Kate Pinnion, Victor Oreffo, Martyn Foster and Kent E Pinkerton
    Citation: Respiratory Research 2009 10:118
  26. Glycosylation on the globular head of the hemagglutinin (HA) protein of influenza virus acts as an important target for recognition and destruction of virus by innate immune proteins of the collectin family. T...

    Authors: Patrick C Reading, Danielle L Pickett, Michelle D Tate, Paul G Whitney, Emma R Job and Andrew G Brooks
    Citation: Respiratory Research 2009 10:117
  27. Preterm infants are highly susceptible to lung injury. While both chorioamnionitis and antenatal steroids induce lung maturation, chorioamnionitis is also associated with adverse lung development. We investiga...

    Authors: Jasper V Been, Luc JI Zimmermann, Anne Debeer, Nico Kloosterboer and J Freek van Iwaarden
    Citation: Respiratory Research 2009 10:116
  28. Although both animal and human studies suggested the association between placenta growth factor (PlGF) and chronic obstructive pulmonary disease (COPD), especially lung emphysema, the role of PlGF in the patho...

    Authors: Shih Lung Cheng, Hao Chien Wang, Chong Jen Yu, Po Nien Tsao, Peter Carmeliet, Shi Jung Cheng and Pan Chyr Yang
    Citation: Respiratory Research 2009 10:115
  29. Lysophosphatidic acid (LPA) plays a critical role in airway inflammation through G protein-coupled LPA receptors (LPA1-3). We have demonstrated that LPA induced cytokine and lipid mediator release in human bronch...

    Authors: Yutong Zhao, Jiankun Tong, Donghong He, Srikanth Pendyala, Berdyshev Evgeny, Jerold Chun, Anne I Sperling and Viswanathan Natarajan
    Citation: Respiratory Research 2009 10:114
  30. The major marker utilized to monitor COPD patients is forced expiratory volume in one second (FEV1). However, asingle measurement of FEV1 cannot reliably predict subsequent decline. Recent studies indicate tha...

    Authors: Jeanine M D'Armiento, Steven M Scharf, Michael D Roth, John E Connett, Andrew Ghio, David Sternberg, Jonathan G Goldin, Thomas A Louis, Jenny T Mao, George T O'Connor, Joe W Ramsdell, Andrew L Ries, Neil W Schluger, Frank C Sciurba, Melissa A Skeans, Helen Voelker…
    Citation: Respiratory Research 2009 10:113
  31. The small airway epithelium and alveolar macrophages are exposed to oxidants in cigarette smoke leading to epithelial dysfunction and macrophage activation. In this context, we asked: what is the transcriptome...

    Authors: Brendan J Carolan, Ben-Gary Harvey, Neil R Hackett, Timothy P O'Connor, Patricia A Cassano and Ronald G Crystal
    Citation: Respiratory Research 2009 10:111
  32. Genetic association studies have become an important part of our scientific landscape. This commentary discusses some basic scientific issues which should be considered when reporting and evaluating such studi...

    Authors: Stephen P Peters
    Citation: Respiratory Research 2009 10:109
  33. There is increasing evidence that a specific immune response contributes to the pathogenesis of COPD. B-cell follicles are present in lung tissue and increased anti-elastin titers have been found in plasma of ...

    Authors: Corry-Anke Brandsma, Machteld N Hylkema, Marie Geerlings, Wouter H van Geffen, Dirkje S Postma, Wim Timens and Huib AM Kerstjens
    Citation: Respiratory Research 2009 10:108
  34. Inflammatory process results in lung injury that may lead to pulmonary fibrosis (PF). Here, we described PF in mice infected with H5N1 virus.

    Authors: Jian Qiao, Miaojie Zhang, Jianmin Bi, Xun Wang, Guangcun Deng, Guimei He, Zhihua Luan, Nana Lv, Tong Xu and Lihong Zhao
    Citation: Respiratory Research 2009 10:107
  35. In patients with cystic fibrosis (CF) the architecture of the developing lungs and the ventilation of lung units are progressively affected, influencing intrapulmonary gas mixing and gas exchange. We examined ...

    Authors: Richard Kraemer, Philipp Latzin, Isabelle Pramana, Pietro Ballinari, Sabina Gallati and Urs Frey
    Citation: Respiratory Research 2009 10:106
  36. Human embryonic stem cells (hESC) have the capacity to differentiate in vivo and in vitro into cells from all three germ lineages. The aim of the present study was to investigate the effect of specific culture co...

    Authors: Lindsey Van Haute, Gert De Block, Inge Liebaers, Karen Sermon and Martine De Rycke
    Citation: Respiratory Research 2009 10:105
  37. Airway absorption and bioavailability of inhaled corticosteroids (ICSs) may0020be influenced by differences in pharmacokinetic properties such as lipophilicity and patient characteristics such as lung function...

    Authors: Chris Dalby, Tomasz Polanowski, Thomas Larsson, Lars Borgström, Staffan Edsbäcker and Tim W Harrison
    Citation: Respiratory Research 2009 10:104
  38. The aim of the present study was to explore the occurrence of fibrocytes in tissue and to investigate whether the appearance of fibrocytes may be linked to structural changes of the parenchyme and vasculature ...

    Authors: Annika Andersson-Sjöland, Jonas S Erjefält, Leif Bjermer, Leif Eriksson and Gunilla Westergren-Thorsson
    Citation: Respiratory Research 2009 10:103
  39. Highly pathogenic avian influenza (HPAI) H5N1 virus is entrenched in poultry in Asia and Africa and continues to infect humans zoonotically causing acute respiratory disease syndrome and death. There is eviden...

    Authors: Michael CW Chan, Renee WY Chan, Wendy CL Yu, Carol CC Ho, WH Chui, CK Lo, Kit M Yuen, Yi Guan, John M Nicholls and JS Malik Peiris
    Citation: Respiratory Research 2009 10:102
  40. The randomized placebo-controlled IFIGENIA-trial demonstrated that therapy with high-dose N-acetylcysteine (NAC) given for one year, added to prednisone and azathioprine, significantly ameliorates (i.e. slows ...

    Authors: Jürgen Behr, Maurits Demedts, Roland Buhl, Ulrich Costabel, Richard PN Dekhuijzen, Henk M Jansen, William MacNee, Michiel Thomeer, Benoit Wallaert, Francois Laurent, Andrew G Nicholson, Eric K Verbeken, Johny Verschakelen, CDR Flower, Stefano Petruzzelli, Paul De Vuyst…
    Citation: Respiratory Research 2009 10:101
  41. Chronic persistent asthma is characterized by ongoing airway inflammation and airway remodeling. The processes leading to airway remodeling are poorly understood, and there is increasing evidence that even agg...

    Authors: Astrid M Doerner and Bruce L Zuraw
    Citation: Respiratory Research 2009 10:100
  42. The study of small airway diseases such as post-transplant bronchiolitis obliterans syndrome (BOS) is hampered by the difficulty in assessing peripheral airway function either physiologically or directly. Our ...

    Authors: Balarka Banerjee, Anthony Kicic, Michael Musk, Erika N Sutanto, Stephen M Stick and Daniel C Chambers
    Citation: Respiratory Research 2009 10:99
  43. Genetic variants at the vitamin D receptor (VDR) locus are associated with asthma and atopy. We hypothesized that polymorphisms in other genes of the vitamin D pathway are associated with asthma or atopy.

    Authors: Yohan Bossé, Mathieu Lemire, Audrey H Poon, Denise Daley, Jian-Qing He, Andrew Sandford, John H White, Alan L James, William Arthur Musk, Lyle J Palmer, Benjamin A Raby, Scott T Weiss, Anita L Kozyrskyj, Allan Becker, Thomas J Hudson and Catherine Laprise
    Citation: Respiratory Research 2009 10:98
  44. Bronchus-associated lymphoid tissue (BALT) is the secondary lymphoid tissue in bronchial mucosa and is involved in the development of bronchopulmonary immune responses. Although migration of lymphocytes from b...

    Authors: Nakaaki Kawamata, Baohui Xu, Hiroo Nishijima, Kohji Aoyama, Mayumi Kusumoto, Toru Takeuchi, Chuwa Tei, Sara A Michie and Takami Matsuyama
    Citation: Respiratory Research 2009 10:97
  45. Severe pulmonary arterial hypertension, whether idiopathic or secondary, is characterized by structural alterations of microscopically small pulmonary arterioles. The vascular lesions in this group of pulmonar...

    Authors: Seiichiro Sakao, Koichiro Tatsumi and Norbert F Voelkel
    Citation: Respiratory Research 2009 10:95

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