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  1. A decline in forced expiratory volume (FEV1) is a hallmark of respiratory diseases that are an important cause of morbidity among the elderly. While some data exist on biomarkers that are related to FEV1, we s...

    Authors: Gisli Thor Axelsson, Thorarinn Jonmundsson, Youngjae Woo, Elisabet Alexandra Frick, Thor Aspelund, Joseph J. Loureiro, Anthony P. Orth, Lori L. Jennings, Gunnar Gudmundsson, Valur Emilsson, Valborg Gudmundsdottir and Vilmundur Gudnason
    Citation: Respiratory Research 2024 25:44
  2. Randomised control trials (RCTs) with strict eligibility criteria can lead to trial populations not commonly seen in clinical practice. We described the proportion of people with chronic obstructive pulmonary ...

    Authors: Hannah R. Whittaker, Aria Torkpour and Jennifer Quint
    Citation: Respiratory Research 2024 25:43
  3. Good biological indicators capable of predicting chronic obstructive pulmonary disease (COPD) phenotypes and clinical trajectories are lacking. Because nuclear and mitochondrial genomes are damaged and release...

    Authors: Sarah A. Ware, Corrine R. Kliment, Luca Giordano, Kevin M. Redding, William L. Rumsey, Stewart Bates, Yingze Zhang, Frank C. Sciurba, S. Mehdi Nouraie and Brett A. Kaufman
    Citation: Respiratory Research 2024 25:42
  4. Patients with fibrotic hypersensitivity pneumonitis (f-HP) have varied clinical and radiologic presentations whose associated phenotypic outcomes have not been previously described. We conducted a study to eva...

    Authors: Tananchai Petnak, Wisit Cheungpasitporn, Charat Thongprayoon, Tulaton Sodsri, Supawit Tangpanithandee and Teng Moua
    Citation: Respiratory Research 2024 25:41
  5. Although EGFR-TKI resistance mechanisms in non-small cell lung cancer (NSCLC) have been extensively studied, certain patient subgroups remain with unclear mechanisms. This retrospective study analysed mutation...

    Authors: Wuwu Ding, Pengmin Yang, Xiaokai Zhao, Xiaozhi Wang, Huaqing Liu, Qing Su, Xintao Wang, Jieyi Li, Ziying Gong, Daoyun Zhang and Xinwei Wang
    Citation: Respiratory Research 2024 25:40
  6. Chronic obstructive pulmonary disease (COPD) is an inflammatory multisystemic disease caused by environmental exposures and/or genetic factors. Inherited alpha-1-antitrypsin deficiency (AATD) is one of the best ...

    Authors: Daniela Zöller, Christian Haverkamp, Adeline Makoudjou, Ghislain Sofack, Saskia Kiefer, Denis Gebele, Michelle Pfaffenlehner, Martin Boeker, Harald Binder, Kapil Karki, Christian Seidemann, Bernd Schmeck, Timm Greulich, Harald Renz, Stefanie Schild, Susanne A. Seuchter…
    Citation: Respiratory Research 2024 25:38
  7. Acute respiratory distress syndrome (ARDS) alters the dynamics of lung inflation during mechanical ventilation. Repetitive alveolar collapse and expansion (RACE) predisposes the lung to ventilator-induced lung...

    Authors: Hassan Al-Khalisy, Gary F. Nieman, Michaela Kollisch-Singule, Penny Andrews, Luigi Camporota, Joseph Shiber, Toni Manougian, Joshua Satalin, Sarah Blair, Auyon Ghosh, Jacob Herrmann, David W. Kaczka, Donald P. Gaver, Jason H. T. Bates and Nader M. Habashi
    Citation: Respiratory Research 2024 25:37
  8. This study aimed to investigate the interactions among three core elements of respiratory infection—pathogen, lung microbiome, and host response—and their avocation with the severity and outcomes of Mycoplasma pn...

    Authors: Xia Huang, Yingying Luo, Jing Wang, Xuefang Zhang, Lei Chen, Ruxi Wu, Zhengyang Xue, Haiyan Gu, Daiying Li, Heng Tang, Houbing Qin, Deyu Zhao and Feng Liu
    Citation: Respiratory Research 2024 25:35
  9. COVID-19-induced acute respiratory distress syndrome (ARDS) can result in tissue damage and multiple organ dysfunction, especially in kidney transplant recipients (KTRs) receiving immunosuppressive drugs. Pres...

    Authors: Junyu Lu, Yin Chen, Kaihuan Zhou, Yicong Ling, Qianqian Qin, Weisheng Lu, Lian Qin, Chenglin Mou, Jianfeng Zhang, Xiaowen Zheng and Ke Qin
    Citation: Respiratory Research 2024 25:34
  10. No single pulmonary function test captures the functional effect of emphysema in idiopathic pulmonary fibrosis (IPF). Without experienced radiologists, other methods are needed to determine emphysema extent. H...

    Authors: Athol U. Wells, Joseph Jacob, Nicola Sverzellati, Gary Cross, Joseph Barnett, Angelo De Lauretis, Katerina Antoniou, Derek Weycker, Mark Atwood, Klaus-Uwe Kirchgaessler and Vincent Cottin
    Citation: Respiratory Research 2024 25:33
  11. Breath testing using an electronic nose has been recognized as a promising new technique for the early detection of lung cancer. Imbalanced data are commonly observed in electronic nose studies, but methods to...

    Authors: Ke-Cheng Chen, Shuenn-Wen Kuo, Ruei-Hao Shie and Hsiao-Yu Yang
    Citation: Respiratory Research 2024 25:32
  12. Drug-induced interstitial lung disease (DILD) is a lung injury caused by various types of drugs and is a serious problem in both clinical practice and drug development. Clinical management of the condition wou...

    Authors: Yuchen Sun, Kosuke Saito, Atsuhito Ushiki, Mitsuhiro Abe, Yoshinobu Saito, Takeru Kashiwada, Yasushi Horimasu, Akihiko Gemma, Koichiro Tatsumi, Noboru Hattori, Kenji Tsushima, Kazuhisa Takemoto, Rika Ishikawa, Toshiko Momiyama, Shin-ichiro Matsuyama, Noriaki Arakawa…
    Citation: Respiratory Research 2024 25:31
  13. Tissue-engineered tracheal grafts (TETG) can be recellularized by the host or pre-seeded with host-derived cells. However, the impact of airway disease on the recellularization process is unknown.

    Authors: Lisa Zhang, Natalie Kelly, Kimberly M Shontz, Cynthia L. Hill, Jacob T. Stack, Jazmin Calyeca, Laura Matrka, Audrey Miller, Susan D Reynolds and Tendy Chiang
    Citation: Respiratory Research 2024 25:28
  14. Venovenous extracorporeal membrane oxygenation (VV ECMO) has been widely used for severe acute respiratory distress syndrome (ARDS) in recent years. However, the role of hemoadsorption in ARDS patients requiri...

    Authors: Wenli Li, Yuansen Chen, Duo Li, Xiangyan Meng, Ziquan Liu, Yanqing Liu and Haojun Fan
    Citation: Respiratory Research 2024 25:27
  15. Honeycomb cysts (HC) within the alveolar region are distinct histopathological features in the lungs of idiopathic pulmonary fibrosis (IPF) patients. HC are lined with a single-or stratified layer of basal cel...

    Authors: Sabrina Blumer, Petra Khan, Nataliia Artysh, Linda Plappert, Spasenija Savic, Lars Knudsen, Danny Jonigk, Mark P. Kuehnel, Antje  Prasse and Katrin E. Hostettler
    Citation: Respiratory Research 2024 25:26
  16. Drug-induced interstitial lung disease (DIILD) is a serious adverse event potentially induced by any antineoplastic agent. Whether cancer patients are predisposed to a higher risk of DIILD after receiving immu...

    Authors: Yoshihiro Kitahara, Yusuke Inoue, Hideki Yasui, Masato Karayama, Yuzo Suzuki, Hironao Hozumi, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Kazuhito Funai, Tetsuya Honda, Kiyoshi Misawa, Hideaki Miyake, Hiroya Takeuchi, Naoki Inui and Takafumi Suda
    Citation: Respiratory Research 2024 25:25
  17. The substantial heterogeneity of clinical presentations in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia still requires robust chest computed tomography analysis to ident...

    Authors: Yusuke Kataoka, Naoya Tanabe, Masahiro Shirata, Nobuyoshi Hamao, Issei Oi, Tomoki Maetani, Yusuke Shiraishi, Kentaro Hashimoto, Masatoshi Yamazoe, Hiroshi Shima, Hitomi Ajimizu, Tsuyoshi Oguma, Masahito Emura, Kazuo Endo, Yoshinori Hasegawa, Tadashi Mio…
    Citation: Respiratory Research 2024 25:24
  18. Electronic cigarette (e-cig) vaping has increased in the past decade in the US, and e-cig use is misleadingly marketed as a safe cessation for quitting smoking. The main constituents in e-liquid are humectants...

    Authors: Qixin Wang, Joseph H Lucas, Cortney Pang, Ruogang Zhao and Irfan Rahman
    Citation: Respiratory Research 2024 25:23
  19. Malignant pleural effusion is mostly a complication of advanced malignant tumors. However, the cancer markers such as carbohydrate antigen 125 (CA 125), carbohydrate antigen 15-3 (CA 15-3), carbohydrate antige...

    Authors: Xiaoqiong Wang, Xingya Yan, Zhipeng Zhang, Chuchu Xu, Fangbin Du, Yanghu Xie, Xiaona Yin, Zubao Lei, Yinling Jiang, Wanchun Yang, Xuan Zhou and Yongsheng Wang
    Citation: Respiratory Research 2024 25:22
  20. Dyspnea conveys an upsetting or distressing experience of breathing awareness. It heavily weighs on chronic respiratory disease patients, particularly when it persists despite maximal treatment of causative ab...

    Authors: Jonathan Dedonder, Christelle Gelgon, Antoine Guerder, Nathalie Nion, Sophie Lavault, Capucine Morélot-Panzini, Jésus Gonzalez-Bermejo, Laelia Benoit, Thomas Similowski and Laure Serresse
    Citation: Respiratory Research 2024 25:21
  21. The complement system is an important arm of immune defense bringing innate and adaptive immunity. Although originally regarded as a major complementary defense mechanism against pathogens, continuously emergi...

    Authors: M. G. Detsika, K. Palamaris, I. Dimopoulou, A. Kotanidou and S. E. Orfanos
    Citation: Respiratory Research 2024 25:20
  22. Spontaneous intracerebral hemorrhage (ICH) is a condition associated with high mortality and morbidity. Survivors may require prolonged intubation with mechanical ventilation (MV). The aim of this study was to...

    Authors: Ue-Cheung Ho, Chia-Jung Hsieh, Hsueh-Yi Lu, Abel Po-Hao Huang and Lu-Ting Kuo
    Citation: Respiratory Research 2024 25:19
  23. Adenosine deaminase (ADA) is a useful biomarker for the diagnosis of tuberculous pleurisy (TBP). However, pleural effusions with high ADA can also be caused by other diseases, particularly hematologic malignan...

    Authors: Junsu Choe, Sun Hye Shin, Kyeongman Jeon, Hee Jae Huh, Hyung-Doo Park and Byeong-Ho Jeong
    Citation: Respiratory Research 2024 25:17
  24. Growing evidence from observational studies and clinical trials suggests that the gut microbiota is associated with tuberculosis (TB). However, it is unclear whether any causal relationship exists between them...

    Authors: Zongxiang Yuan, Yiwen Kang, Chuye Mo, Shihui Huang, Fang Qin, Junhan Zhang, Fengyi Wang, Junjun Jiang, Xiaoxiang Yang, Hao Liang and Li Ye
    Citation: Respiratory Research 2024 25:16
  25. Aging is associated with an increased incidence and mortality of Pseudomonas aeruginosa-induced pneumonias. This might be partly due to age-dependent increases in inflammatory mediators, referred to as inflamm-ag...

    Authors: Charline Sommer, Stella Marie Reamon-Buettner, Monika Niehof, Christina Beatrix Hildebrand, Armin Braun, Katherina Sewald, Susann Dehmel and Christina Brandenberger
    Citation: Respiratory Research 2024 25:15
  26. Ambient fine particulate matter (PM2.5) is considered a plausible contributor to the onset of chronic obstructive pulmonary disease (COPD). Mechanistic studies are needed to augment t...

    Authors: Zhang-fu Fang, Zhao-ni Wang, Zhe Chen, Yang Peng, Yu Fu, Yang Yang, Hai-long Han, Yan-bo Teng, Wei Zhou, Damo Xu, Xiao-yu Liu, Jia-xing Xie, Junfeng (Jim) Zhang and Nan-shan Zhong
    Citation: Respiratory Research 2024 25:14
  27. While regular cigar smoking is believed to carry similar health risks as regular cigarette smoking, the impact of cigar use, alone or in combination with cigarettes, on obstructive pulmonary disease (COPD) has...

    Authors: Steven Cook, James H. Buszkiewicz, David T. Levy, Rafael Meza and Nancy L. Fleischer
    Citation: Respiratory Research 2024 25:13

    The Correction to this article has been published in Respiratory Research 2024 25:98

  28. There are relatively few data about the ultrasound evaluation of pleural line in patients with respiratory failure. We measured the pleural line thickness during different phases of the respiratory cycle in ne...

    Authors: Barbara Loi, Pasquale Fabio Barra, Laura Vivalda, Francesco Raimondi and Daniele De Luca
    Citation: Respiratory Research 2024 25:12
  29. Vitamin D has been suggested to influence the immune system, and vitamin D metabolites and the vitamin D receptor (VDR) are generated and expressed in white blood cells (WBC). Moreover, vitamin D status has be...

    Authors: Gustav Wall-Gremstrup, Rune Holt, Sam Kafai Yahyavi, Mads Joon Jorsal, Anders Juul, Niels Jørgensen and Martin Blomberg Jensen
    Citation: Respiratory Research 2024 25:11
  30. Although Traditional Chinese Medicine (TCM) has been used for treating asthma for centuries, the understanding of its mechanism of action is still limited. Thus, the purpose of this study was to explore the po...

    Authors: Wang Peng, Qinxuan Xia, Yue Zhang, Danfeng Cao and Xiangrong Zheng
    Citation: Respiratory Research 2024 25:10
  31. Patients with influenza-related acute respiratory distress syndrome (ARDS) are critically ill and require mechanical ventilation (MV) support. Prolonged mechanical ventilation (PMV) is often seen in these case...

    Authors: Pai-Chi Hsu, Yi-Tsung Lin, Kuo-Chin Kao, Chung-Kan Peng, Chau-Chyun Sheu, Shinn-Jye Liang, Ming-Cheng Chan, Hao-Chien Wang, Yu-Mu Chen, Wei-Chih Chen and Kuang-Yao Yang
    Citation: Respiratory Research 2024 25:9
  32. The mortality rate of acute respiratory distress syndrome (ARDS) increases with age (≥ 65 years old) in critically ill patients, and it is necessary to prevent mortality in elderly patients with ARDS in the in...

    Authors: Mingzhuo Li, Fen Liu, Yang Yang, Jiahui Lao, Chaonan Yin, Yafei Wu, Zhongshang Yuan, Yongyue Wei and Fang Tang
    Citation: Respiratory Research 2024 25:8
  33. Excessive pulmonary inflammation is the hallmark of respiratory syncytial virus (RSV) infection hindering efficacious RSV vaccine development. Yet, the vast majority of the experimental RSV vaccine studies use...

    Authors: Min-Ju Kim, Ki Back Chu, Su-Hwa Lee, Jie Mao, Gi-Deok Eom, Keon-Woong Yoon, Eun-Kyung Moon and Fu-Shi Quan
    Citation: Respiratory Research 2024 25:7
  34. Airway remodeling is a poorly reversible feature of asthma which lacks effective therapeutic interventions. CD147 can regulate extracellular matrix (ECM) remodeling and tissue fibrosis, and participate in the ...

    Authors: Zhao Li, Tao Cheng, Yaning Guo, Rong Gao, Xuankun Ma, Xuecong Mao and Xinpeng Han
    Citation: Respiratory Research 2024 25:6
  35. Interstitial lung diseases (ILD) comprise a heterogeneous group of mainly chronic lung diseases with more than 200 entities and relevant differences in disease course and prognosis. Little data is available on...

    Authors: Katharina Buschulte, Hans-Joachim Kabitz, Lars Hagmeyer, Peter Hammerl, Albert Esselmann, Conrad Wiederhold, Dirk Skowasch, Christoph Stolpe, Marcus Joest, Stefan Veitshans, Marc Höffgen, Phillen Maqhuzu, Larissa Schwarzkopf, Andreas Hellmann, Michael Pfeifer, Jürgen Behr…
    Citation: Respiratory Research 2024 25:5
  36. Lung recruitment and continuous distending pressure (CDP) titration are critical for assuring the efficacy of high-frequency ventilation (HFOV) in preterm infants. The limitation of oxygenation (peripheral oxy...

    Authors: Chiara Veneroni, Raffaele L. Dellacà, Erik Küng, Beatrice Bonomi, Angelika Berger and Tobias Werther
    Citation: Respiratory Research 2024 25:4
  37. Chronic lung diseases such as chronic obstructive pulmonary disease and cystic fibrosis are incurable. Epithelial senescence, a state of dysfunctional cell cycle arrest, contributes to the progression of such ...

    Authors: Michelle Brand, Felix Ritzmann, Kathrin Kattler, Deivydas Milasius, Yiwen Yao, Christian Herr, Susanne H. Kirsch, Rolf Müller, Daniela Yildiz, Robert Bals and Christoph Beisswenger
    Citation: Respiratory Research 2024 25:3
  38. Accurately distinguishing between pulmonary infection and colonization in patients with Acinetobacter baumannii is of utmost importance to optimize treatment and prevent antibiotic abuse or inadequate therapy. An...

    Authors: Zhaodong Zeng, Jiefang Wu, Genggeng Qin, Dong Yu, Zilong He, Weixiong Zeng, Hao Zhou, Jiongbin Lin, Laiyu Liu, Chunxia Qi and Weiguo Chen
    Citation: Respiratory Research 2024 25:2
  39. The Acute Respiratory Distress Syndrome (ARDS) is characterized by lung inflammation and edema, impairing both oxygenation and lung compliance. Recent studies reported a dissociation between oxygenation and co...

    Authors: Eleni Papoutsi, Ioannis Andrianopoulos, Vasiliki Mavrikaki, Maria Bolaki, Vagia Stamatopoulou, Eleni Toli, Georgios Papathanakos, Vasilios Koulouras, Eumorfia Kondili, Ilias I. Siempos and Katerina Vaporidi
    Citation: Respiratory Research 2024 25:1
  40. Pulmonary Langerhans cell histiocytosis (PLCH) is a rare interstitial lung disease (ILD) associated with smoking, whose definitive diagnosis requires the exclusion of other forms of ILD and a compatible surgic...

    Authors: Silvia Barril, Paloma Acebo, Paloma Millan-Billi, Alfonso Luque, Oriol Sibila, Carlos Tarín, Abdellatif Tazi, Diego Castillo and Sonsoles Hortelano
    Citation: Respiratory Research 2023 24:320
  41. Mitochondrial dysfunction and lung cellular senescence are significant features involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Cigarette smoke (CS) stands as the primary contribu...

    Authors: Chenfei Li, Qi Liu, Qing Chang, Meiqin Xie, Jiali Weng, Xiaohui Wang, Mengnan Li, Jiani Chen, Yan Huang, Xiaohua Yang, Kai Wang, Na Zhang, Kian Fan Chung, Ian M. Adcock, Hai Zhang and Feng Li
    Citation: Respiratory Research 2023 24:319
  42. Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease (ILD) with unknown etiology, characterized by sustained damage repair of epithelial cells and abnormal activation of fibroblasts, ...

    Authors: Caoyuan Niu, Kai Xu, Yanan Hu, Yanling Jia, Yuexia Yang, Xiaoyue Pan, Ruyan Wan, Hui Lian, Qiwen Wang, Juntang Yang, Yajun Li, Ivan Rosas, Lan Wang and Guoying Yu
    Citation: Respiratory Research 2023 24:318
  43. Cystic fibrosis (CF) is a genetic disorder causing poor mucociliary clearance in the airways and subsequent respiratory infection. The recently approved triple therapy Elexacaftor–Tezacaftor–Ivacaftor (ETI) ha...

    Authors: Christian Martin, Douglas V. Guzior, Cely T. Gonzalez, Maxwell Okros, Jenna Mielke, Lienwil Padillo, Gabriel Querido, Marissa Gil, Ryan Thomas, Marc McClelland, Doug Conrad, Stefanie Widder and Robert A. Quinn
    Citation: Respiratory Research 2023 24:317
  44. Over the last ten years an increasing prevalence and incidence of non-tuberculous mycobacteria (NTM) has been reported among patients with cystic fibrosis (CF) Viviani (J Cyst Fibros, 15(5):619–623, 2016). NTM...

    Authors: Andrea Gramegna, Sofia Misuraca, Andrea Lombardi, Chiara Premuda, Ivan Barone, Margherita Ori, Francesco Amati, Mariangela Retucci, Erica Nazzari, Gianfranco Alicandro, Maurizio Ferrarese, Luigi Codecasa, Alessandra Bandera, Stefano Aliberti, Valeria Daccò and Francesco Blasi
    Citation: Respiratory Research 2023 24:316
  45. The two-way communications along the gut-lung axis influence the immune function in both gut and lung. However, the shared genetic characteristics of lung function with gastrointestinal tract (GIT) diseases re...

    Authors: Minghui Jiang, Xingjie Hao, Yi Jiang, Si Li, Chaolong Wang and Shanshan Cheng
    Citation: Respiratory Research 2023 24:315
  46. Recent data from human studies and animal models have established roles for type II alveolar epithelial cell (AEC2) injury/apoptosis and monocyte/macrophage accumulation and activation in progressive lung fibr...

    Authors: Doyun Kwak, Patrick B. Bradley, Natalia Subbotina, Song Ling, Seagal Teitz-Tennenbaum, John J. Osterholzer, Thomas H. Sisson and Kevin K. Kim
    Citation: Respiratory Research 2023 24:314
  47. Sporadic studies have examined the impact of OSA on ACS patients by homocysteine (Hcy) level. This study attempted to comprehensively evaluate the effects of the interaction between Hcy and OSA on long-term ca...

    Authors: Xiuhuan Chen, Lei Zhen, Hui Ai, Bin Que, Jingyao Fan, Xiao Wang, Yan Yan, Siyi Li, Zekun Zhang, Yun Zhou, Wei Gong and Shaoping Nie
    Citation: Respiratory Research 2023 24:313

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