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  1. Pulmonary fibrosis (PF) represents the pathologic end stage of several interstitial lung diseases (ILDs) associated with high morbidity and mortality rates. However, current treatments can only delay disease p...

    Authors: Catarina Barbosa-Matos, Caroline Borges-Pereira, Sofia Libório-Ramos, Raquel Fernandes, Marcela Oliveira, Ana Mendes-Frias, Ricardo Silvestre, Nuno S. Osório, Hélder N. Bastos, Rita F. Santos, Susana Guimarães, António Morais, Massimiliano Mazzone, Agostinho Carvalho, Cristina Cunha and Sandra Costa
    Citation: Respiratory Research 2024 25:257
  2. Patients receiving PD-(L)1 inhibitors frequently encounter unusual side effects known as immune-related adverse events (irAEs). However, the correlation of irAEs development with clinical response in small cel...

    Authors: Jian Zhang, Aiqin Gao, Shuyun Wang, Yanxin Sun, Jiake Wu, Dahai Wang, Yihui Ge, Juan Li, Haifeng Sun, Qinglei Cheng and Yuping Sun
    Citation: Respiratory Research 2024 25:256
  3. Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease (ILD) with a high mortality rate. The antifibrotic medications pirfenidone and nintedanib have been in use since 2014 for this dis...

    Authors: Cathryn T. Lee, Wei Hao, Cindy A. Burg, Jennie Best, Giselle E. Kolenic and Mary E. Strek
    Citation: Respiratory Research 2024 25:255
  4. Tuberculosis (TB) remains the second leading cause of death from a single infectious agent and long-term medication could lead to antituberculosis drug-induced liver injury (ATB-DILI). We established a prospec...

    Authors: Mengjiao Li, Dan Zhang, Qingxin Yang, Zhenzhen Zhao, Chunying Zhang, Yanbing Zhou, Yangjuan Bai, Lu Chen, Xiaoyan Tang, Cuihua Liu, Juan Zhou, Xuerong Chen and Binwu Ying
    Citation: Respiratory Research 2024 25:254
  5. There is a desperate for the identification of more accurate and efficient biomarkers for ICI responses in patients with SCLC.

    Authors: Chenyue Zhang, Yanfei Huo, Xiaoling Shang, Tongming Zhang, Ning Tang and Haiyong Wang
    Citation: Respiratory Research 2024 25:253
  6. To assess the effectiveness of HRCT-based radiomics in predicting rapidly progressive interstitial lung disease (RP-ILD) and mortality in anti-MDA5 positive dermatomyositis-related interstitial lung disease (a...

    Authors: Wenzhang He, Beibei Cui, Zhigang Chu, Xiaoyi Chen, Jing Liu, Xueting Pang, Xuan Huang, Hongkun Yin, Hui Lin and Liqing Peng
    Citation: Respiratory Research 2024 25:252
  7. The impact of chronic obstructive pulmonary disease (COPD) on outcome in perioperative organ injury (POI) has not yet been investigated sufficiently.

    Authors: Nadine Hochhausen, Mare Mechelinck, Andreas Kroh, Rolf Rossaint and Felix Kork
    Citation: Respiratory Research 2024 25:251
  8. Lower respiratory tract infections(LRTIs) in adults are complicated by diverse pathogens that challenge traditional detection methods, which are often slow and insensitive. Metagenomic next-generation sequenci...

    Authors: Qinghua Gao, Lingyi Li, Ting Su, Jie Liu, Liping Chen, Yongning Yi, Yun Huan, Jian He and Chao Song
    Citation: Respiratory Research 2024 25:250
  9. Our study examined whether prevalent and incident comorbidities are increased in idiopathic pulmonary fibrosis (IPF) patients when compared to matched chronic obstructive pulmonary disease (COPD) patients and ...

    Authors: Burcu Ozaltin, Robert Chapman, Muhammad Qummer Ul Arfeen, Natalie Fitzpatick, Harry Hemingway, Kenan Direk and Joseph Jacob
    Citation: Respiratory Research 2024 25:249
  10. The term “post-COVID-19 condition” refers to the symptomatology that appears between four to twelve weeks after Covid-19 infection. These symptoms can persist for weeks or even months, significantly diminishin...

    Authors: Lucía Ortiz-Ortigosa, Paula Gálvez-Álvarez, María Jesús Viñolo-Gil, Manuel Rodriguez-Huguet, Jorge Góngora-Rodríguez and Rocío Martín-Valero
    Citation: Respiratory Research 2024 25:248
  11. Sleep-disordered breathing (SDB) is a major comorbidity in idiopathic pulmonary fibrosis (IPF) and is associated with a poor outcome. There is a lack of knowledge regarding the impact of SDB treatment on IPF. ...

    Authors: Jaume Bordas-Martinez, Neus Salord, Vanesa Vicens-Zygmunt, João Carmezim, Sandra Pérez, Eliseo Prado, María Calvo, Rosana Blavia, Guadalupe Bermudo, Salud Santos, Carmen Monasterio and María Molina-Molina
    Citation: Respiratory Research 2024 25:247
  12. There is no individualized prediction model for intensive care unit (ICU) admission on patients with community-acquired pneumonia (CAP) and connective tissue disease (CTD) so far. In this study, we aimed to es...

    Authors: Dong Huang, Linjing Gong, Chang Wei, Xinyu Wang and Zongan Liang
    Citation: Respiratory Research 2024 25:246
  13. Evidence suggests that radiotherapy is a potent immunomodulator in non-small cell lung cancer (NSCLC). Conversely, it has rarely been demonstrated if immune infiltration can influence radiotherapy efficacy. He...

    Authors: Jiaran Li, Li Li, Jingjing Wang, Ning Liu, Haixin Liu, Fuhao Xu, Mengke Li and Shuanghu Yuan
    Citation: Respiratory Research 2024 25:244
  14. The endeavor of liberating patients from ventilator dependence within respiratory care centers (RCCs) poses considerable challenges. Multiple factors contribute to this process, yet establishing an effective r...

    Authors: Shiauyee Chen, Shu-Fen Liao, Yun-Jou Lin, Chao-Ying Huang, Shu-Chuan Ho and Jer-Hwa Chang
    Citation: Respiratory Research 2024 25:243
  15. Silicosis represents a paramount occupational health hazard globally, with its incidence, morbidity, and mortality on an upward trajectory, posing substantial clinical dilemmas due to limited effective treatme...

    Authors: Fengqin Zhang, Huihui Yue, Ruihan Dong, Jianhan He, Ling Zhou, Xinran Dou, lingling Wang, Pengdou Zheng, Zhenyu Mao, Xiaoyan Zhu, Yi Wang, Huiguo Liu and Huilan Zhang
    Citation: Respiratory Research 2024 25:242
  16. Idiopathic pulmonary fibrosis (IPF) is a chronic disease of unknown etiology that lacks a specific treatment. In IPF, macrophages play a key regulatory role as a major component of the lung immune system, espe...

    Authors: Hao Zhang, Yuwei Yang, Yan Cao and Jingzhi Guan
    Citation: Respiratory Research 2024 25:241
  17. Despite the success of antiretroviral therapy (ART), people living with HIV (PLWH) suffer from a high burden of pulmonary diseases, even after accounting for their smoking status. Cytotoxic CD8 T-cells are lik...

    Authors: Yulia Alexandrova, Alexis Yero, Ronald Olivenstein, Marianna Orlova, Erwin Schurr, Jerome Estaquier, Cecilia T. Costiniuk and Mohammad-Ali Jenabian
    Citation: Respiratory Research 2024 25:240
  18. In familial pulmonary fibrosis (FPF) at least two biological relatives are affected. Patients with FPF have diverse clinical features.

    Authors: Hanna Jaula, Lauri Mattila, Elisa Lappi-Blanco, Johanna Salonen, Hannu Vähänikkilä, Lauri Ahvenjärvi, Jukka S. Moilanen, Outi Kuismin, Terttu Harju and Riitta Kaarteenaho
    Citation: Respiratory Research 2024 25:239
  19. The effect of dual systemic antibiotic therapy against Pseudomonas aeruginosa in patients with pre-existing lung disease is unknown. To assess whether dual systemic antibiotics against P. aeruginosa in outpatient...

    Authors: Josefin Eklöf, Imane Achir Alispahic, Karin Armbruster, Therese Sophie Lapperre, Andrea Browatzki, Rikke Holmen Overgaard, Zitta Barrella Harboe, Julie Janner, Mia Moberg, Charlotte Suppli Ulrik, Helle Frost Andreassen, Ulla Møller Weinreich, Jakob Lyngby Kjærgaard, Jenny Villadsen, Camilla Sund Fenlev, Torben Tranborg Jensen…
    Citation: Respiratory Research 2024 25:236
  20. Abnormal remodeling of distal pulmonary arteries in patients with pulmonary arterial hypertension (PAH) leads to progressively increased pulmonary vascular resistance, followed by right ventricular hypertrophy...

    Authors: Li Gao, John Skinner, Tanmay Nath, Qing Lin, Megan Griffiths, Rachel L. Damico, Michael W. Pauciulo, William C. Nichols, Paul M. Hassoun, Allen D. Everett and Roger A. Johns
    Citation: Respiratory Research 2024 25:235
  21. The concurrent circulation of SARS-CoV-2 with other respiratory viruses is unstoppable and represents a new diagnostic reality for clinicians and clinical microbiology laboratories. Multiplexed molecular testi...

    Authors: Manca Luštrek, Zala Cesar, Alen Suljič, Rok Kogoj, Nataša Knap, Monika Jevšnik Virant, Tina Uršič, Miroslav Petrovec, Tatjana Avšič-Županc and Miša Korva
    Citation: Respiratory Research 2024 25:234
  22. There is inconclusive evidence to suggest that the expression of programmed cell death ligand 1 (PD-L1) is a putative predictor of response to EGFR-TKI therapy in advanced EGFR-mutant non-small cell lung cance...

    Authors: Yaohua Hu, Yidan Zhang, You Lu, Yingqi Xu, Jianlin Xu, Hua Zhong, Lei Cheng and Runbo Zhong
    Citation: Respiratory Research 2024 25:233
  23. Acute respiratory distress syndrome or ARDS is an acute, severe form of respiratory failure characterised by poor oxygenation and bilateral pulmonary infiltrates. Advancements in signal processing and machine ...

    Authors: Tu K. Tran, Minh C. Tran, Arun Joseph, Phi A. Phan, Vicente Grau and Andrew D. Farmery
    Citation: Respiratory Research 2024 25:232
  24. Precision Cut Lung Slices (PCLS) have emerged as a sophisticated and physiologically relevant ex vivo model for studying the intricacies of lung diseases, including fibrosis, injury, repair, and host defense m...

    Authors: Cynthia Koziol-White, Eric Gebski, Gaoyaun Cao and Reynold A. Panettieri Jr.
    Citation: Respiratory Research 2024 25:231
  25. Airway epithelium is an important component of airway structure and the initiator of airway remodeling in asthma. The changes of extracellular matrix (ECM), such as collagen deposition and structural disturban...

    Authors: Rong Zeng, Dong Zhang, Jintao Zhang, Yun Pan, Xiaofei Liu, Qian Qi, Jiawei Xu, Changjuan Xu, Shuochuan Shi, Junfei Wang, Tian Liu and Liang Dong
    Citation: Respiratory Research 2024 25:230
  26. COPD is associated with the development of lung cancer. A protective effect of inhaled corticosteroids (ICS) on lung cancer is still controversial. Hence, this study investigated the development of lung cancer...

    Authors: Ji Eun Park, Eunyoung Lee, Dave Singh, Eun Kyung Kim, Bumhee Park and Joo Hun Park
    Citation: Respiratory Research 2024 25:229
  27. Respiratory viral infections are major drivers of chronic obstructive pulmonary disease (COPD) exacerbations. Interferon-β is naturally produced in response to viral infection, limiting replication. This explo...

    Authors: Phillip D. Monk, Jody L. Brookes, Victoria J. Tear, Toby N. Batten, Clare Newall, Marcin Mankowski, Michael G. Crooks, Dave Singh, Rekha Chaudhuri, Brian Leaker, Kerry Lunn, Sophie Reynolds, Sarah Dudley, Felicity J. Gabbay, Stephen T. Holgate, Ratko Djukanovic…
    Citation: Respiratory Research 2024 25:228
  28. Steroid insensitivity in Chronic Obstructive Pulmonary Disease (COPD) presents a problem for controlling the chronic inflammation of the airways. The glucocorticoid receptor (GR) mediates the intracellular sig...

    Authors: Liang Zhou, Michael Roth, Eleni Papakonstantinou, Michael Tamm and Daiana Stolz
    Citation: Respiratory Research 2024 25:227
  29. This study aimed to explore the incidence of occult lymph node metastasis (OLM) in clinical T1 − 2N0M0 (cT1 − 2N0M0) small cell lung cancer (SCLC) patients and develop machine learning prediction models using pre...

    Authors: Xu Jiang, Chao Luo, Xin Peng, Jing Zhang, Lin Yang, Li-Zhi Liu, Yan-Fen Cui, Meng-Wen Liu, Lei Miao, Jiu-Ming Jiang, Jia-Liang Ren, Xiao-Tang Yang, Meng Li and Li Zhang
    Citation: Respiratory Research 2024 25:226
  30. The soft palate and back of the throat represent vulnerable early infection sites for SARS-CoV-2, influenza, streptococci, and many other pathogens. We demonstrate that snoring causes aerosolization of pharyng...

    Authors: Tayeb Kakeshpour, Kevin P. Fennelly and Adriaan Bax
    Citation: Respiratory Research 2024 25:224
  31. Community-acquired pneumonia (CAP) is a common and serious condition that can be caused by a variety of pathogens. However, much remains unknown about how these pathogens interact with the lower respiratory co...

    Authors: Jing Yang, Jinman Li, Linfeng Zhang, Zijie Shen, Yan Xiao, Guoliang Zhang, Mingwei Chen, Fuhui Chen, Ling Liu, Ying Wang, Lan Chen, Xinming Wang, Li Zhang, Lu Wang, Zhang Wang, Jianwei Wang…
    Citation: Respiratory Research 2024 25:223
  32. To investigate the association of serum anti-Jo-1 antibody levels with the disease activity and prognosis in anti-Jo-1-positive patients with antisynthetase syndrome (ASS).

    Authors: Hongxia Yang, Qingning Chen, Chao Sun, Qiwen Jin, Lining Zhang, Qingyan Liu, Qinglin Peng, Guochun Wang and Xin Lu
    Citation: Respiratory Research 2024 25:222
  33. Pulmonary hypertension (PH) is regarded as cardiovascular disease with an extremely poor prognosis, primarily due to irreversible vascular remodeling. Despite decades of research progress, the absence of defin...

    Authors: Huixue Ba, Yingfan Guo, Yujie Jiang, Ying Li, Xuejing Dai, Yuan Liu and Xiaohui Li
    Citation: Respiratory Research 2024 25:221
  34. Pulmonary arterial hypertension (PAH) is a complex and progressive illness that has a multifaceted origin, significant fatality rates, and profound effects on health. The pathogenesis of PAH is poorly defined ...

    Authors: Qi Yang, Banghui Lai, Hao Xie, Mingbin Deng, Jun Li, Yan Yang, Juyi Wan, Bin Liao and Feng Liu
    Citation: Respiratory Research 2024 25:220
  35. Large-scale estimates of bronchopulmonary dysplasia (BPD) are warranted for adequate prevention and treatment. However, systematic approaches to ascertain rates of BPD are lacking.

    Authors: Alvaro Moreira, Michelle Noronha, Jooby Joy, Noah Bierwirth, Aina Tarriela, Aliha Naqvi, Sarah Zoretic, Maxwell Jones, Ali Marotta, Taylor Valadie, Jonathan Brick, Caitlyn Winter, Melissa Porter, Isabelle Decker, Matteo Bruschettini and Sunil K. Ahuja
    Citation: Respiratory Research 2024 25:219
  36. Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic interstitial lung disease characterized by progressive dyspnea and decreased lung function, yet its exact etiology remains unclear. It is of great sign...

    Authors: Zetao Liu, Zhiyu Peng, Huahang Lin, Ke Zhou, Linchuan Liang, Jie Cao, Zhaokang Huang and Jiandong Mei
    Citation: Respiratory Research 2024 25:217
  37. The growing concern of pediatric mortality demands heightened preparedness in clinical settings, especially within intensive care units (ICUs). As respiratory-related admissions account for a substantial porti...

    Authors: Johayra Prithula, Muhammad E. H. Chowdhury, Muhammad Salman Khan, Khalid Al-Ansari, Susu M. Zughaier, Khandaker Reajul Islam and Abdulrahman Alqahtani
    Citation: Respiratory Research 2024 25:216
  38. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of lung cancer patients with mutated EGFR. However, the efficacy of EGFR-TKIs in wild-type EGFR tumor...

    Authors: Han Wang, Xiaohui Du, Wenwen Liu, Congcong Zhang, Ying Li, Jingwen Hou, Yi Yu, Guiru Li and Qi Wang
    Citation: Respiratory Research 2024 25:215
  39. Obstructive sleep apnea (OSA) is associated with abnormal glucose and lipid metabolism. However, whether there is an independent association between Sleep Apnea-Specific Hypoxic Burden (SASHB) and glycolipid m...

    Authors: Chenyang Li, Yu Peng, Xiaoyue Zhu, Yupu Liu, Jianyin Zou, Huaming Zhu, Xinyi Li, Hongliang Yi, Jian Guan, Xu Zhang, Huajun Xu and Shankai Yin
    Citation: Respiratory Research 2024 25:214
  40. Obesity is associated with airway hyperresponsiveness and lung fibrosis, which may reduce the effectiveness of standard asthma treatment in individuals suffering from both conditions. Statins and proprotein co...

    Authors: Lin Liang, Sook In Chung, Tae-Eun Guon, Kyung Hee Park, Jae-Hyun Lee and Jung-Won Park
    Citation: Respiratory Research 2024 25:213
  41. Paraquat (PQ) is a widely used herbicide and a common cause of poisoning that leads to pulmonary fibrosis with a high mortality rate. However, the underlying mechanisms of PQ-induced pulmonary fibrosis and whe...

    Authors: Youjia Yu, Chunyan Chu, Kang Wang, Yan Li, Zhengsheng Mao, Li Hu, Jie Wang, Yanfang Yu, Hao Sun and Feng Chen
    Citation: Respiratory Research 2024 25:212
  42. Bronchiectasis is a condition characterized by abnormal and irreversible bronchial dilation resulting from lung tissue damage and can be categorized into two main groups: cystic fibrosis (CF) and non-CF bronch...

    Authors: Heryk Motta, Júlia Catarina Vieira Reuwsaat, Fernanda Cortez Lopes, Graciele Viezzer, Fabiana Caroline Zempulski Volpato, Afonso Luís Barth, Paulo de Tarso Roth Dalcin, Charley Christian Staats, Marilene Henning Vainstein and Lívia Kmetzsch
    Citation: Respiratory Research 2024 25:211
  43. Mitogen-activated protein kinase (MAPK)signaling-mediated smoking-associated pulmonary vascular remodeling (PVR) plays an important role in the pathogenesis of group 3 pulmonary hypertension (PH). And G protei...

    Authors: Ting Hu, Chaohui Mu, Yanmiao Li, Wanming Hao, Xinjuan Yu, Yixuan Wang, Wei Han and Qinghai Li
    Citation: Respiratory Research 2024 25:210
  44. Limited research has investigated the relationship between small airway dysfunction (SAD) and static lung hyperinflation (SLH) in patients with post-acute sequelae of COVID-19 (PASC) especially dyspnea and fat...

    Authors: Po-Chun Lo, Jia-Yih Feng, Yi-Han Hsiao, Kang-Cheng Su, Kun-Ta Chou, Yuh-Min Chen, Hsin-Kuo Ko and Diahn-Warng Perng
    Citation: Respiratory Research 2024 25:209
  45. We estimated the prevalence and mortality risks of preserved ratio impaired spirometry (PRISm) and chronic obstructive pulmonary disease (COPD) in the US adult population.

    Authors: Christopher J. Cadham, Hayoung Oh, MeiLan K. Han, David Mannino, Steven Cook, Rafael Meza, David T. Levy and Luz María Sánchez-Romero
    Citation: Respiratory Research 2024 25:208

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