Skip to main content

Articles

Page 1 of 61

  1. Short-acting β2-agonist (SABA) bronchodilators help alleviate symptoms in chronic obstructive pulmonary disease (COPD) and may be a useful marker of symptom severity. This analysis investigated whether SABA use i...

    Authors: F. Maltais, I. P. Naya, C. F. Vogelmeier, I. H. Boucot, P. W. Jones, L. Bjermer, L. Tombs, C. Compton, D. A. Lipson and E. M. Kerwin

    Citation: Respiratory Research 2020 21:280

    Content type: Research

    Published on:

  2. Tezepelumab is a human monoclonal antibody that blocks the activity of the epithelial cytokine thymic stromal lymphopoietin. The efficacy, safety and oral corticosteroid-sparing potential of tezepelumab are be...

    Authors: Andrew Menzies-Gow, Sandhia Ponnarambil, John Downie, Karin Bowen, Åsa Hellqvist and Gene Colice

    Citation: Respiratory Research 2020 21:279

    Content type: Study protocol

    Published on:

  3. Anti-T2 biological therapies have proven to effectively reduce acute exacerbations and daily doses of oral steroids in severe eosinophilic asthma. Despite the remarkable clinical efficacy, there are usually on...

    Authors: Mustafa Abdo, Henrik Watz, Vera Veith, Anne-Marie Kirsten, Heike Biller, Frauke Pedersen, Erika von Mutius, Matthias V. Kopp, Gesine Hansen, Benjamin Waschki, Klaus F. Rabe, Frederik Trinkmann and Thomas Bahmer

    Citation: Respiratory Research 2020 21:278

    Content type: Letter to the Editor

    Published on:

  4. Prior studies reported that 5 ~ 32% COVID-19 patients were critically ill, a situation that poses great challenge for the management of the patients and ICU resources. We aim to identify independent risk facto...

    Authors: Sijing Cheng, Dingfeng Wu, Jie Li, Yifeng Zou, Yunle Wan, Lihan Shen, Lixin Zhu, Mang Shi, Linlin Hou, Tao Xu, Na Jiao, Yichen Li, Yibo Huang, Zhipeng Tang, Mingwei Xu, Shusong Jiang…

    Citation: Respiratory Research 2020 21:277

    Content type: Research

    Published on:

  5. Severe coronavirus disease 2019 (COVID-19) is frequently associated with hyperinflammation and hyperferritinemia. The latter is related to increased mortality in COVID-19. Still, it is not clear if iron dysmet...

    Authors: Thomas Sonnweber, Anna Boehm, Sabina Sahanic, Alex Pizzini, Magdalena Aichner, Bettina Sonnweber, Katharina Kurz, Sabine Koppelstätter, David Haschka, Verena Petzer, Richard Hilbe, Markus Theurl, Daniela Lehner, Manfred Nairz, Bernhard Puchner, Anna Luger…

    Citation: Respiratory Research 2020 21:276

    Content type: Research

    Published on:

  6. Combined pulmonary fibrosis and emphysema (CPFE) is a heterogeneous clinico-radiological syndrome without a consensus definition. There are limited data on the relation between the amount of parenchymal fibros...

    Authors: Masahiro Nemoto, Yuichiro Nei, Brian Bartholmai, Kazuki Yoshida, Hiroki Matsui, Tamao Nakashita, Shinji Motojima, Masahiro Aoshima and Jay H. Ryu

    Citation: Respiratory Research 2020 21:275

    Content type: Research

    Published on:

  7. To date, most studies involving high-throughput analyses of sputum in asthma and COPD have focused on identifying transcriptomic signatures of disease. No whole-genome methylation analysis of sputum cells has ...

    Authors: Espen E. Groth, Melanie Weber, Thomas Bahmer, Frauke Pedersen, Anne Kirsten, Daniela Börnigen, Klaus F. Rabe, Henrik Watz, Ole Ammerpohl and Torsten Goldmann

    Citation: Respiratory Research 2020 21:274

    Content type: Research

    Published on:

  8. Immunoglobulin G4-related lung disease (IgG4-RLD) is the pulmonary manifestation of a systemic fibroinflammatory disease characterized by lymphoplasmacytic infiltration with an abundance of IgG4-positive plasm...

    Authors: Jieun Kang, Shinhee Park, Eun Jin Chae, Joon Seon Song, Hee Sang Hwang, Sun Jong Kim, Tae Jun Song, Myung-Whan Kim and Jin Woo Song

    Citation: Respiratory Research 2020 21:273

    Content type: Research

    Published on:

  9. The longer upper airway is more collapsible during sleep. This study aims to reveal relationships among upper airway length, weight, and obstructive sleep apnea (OSA), particularly to answer why the upper airw...

    Authors: Hongyi Lin, Huahui Xiong, Changjin Ji, Cunting Wang, Yong Li, Yunqiang An, Geng Li, Jianggui Guo, Xiaoqing Huang, Han Zhang, Hong Liu, Ting Li, Zheng Li, Junfang Xian and Yaqi Huang

    Citation: Respiratory Research 2020 21:272

    Content type: Research

    Published on:

  10. The role of the microbiota in the pathogenesis of chronic obstructive pulmonary disease (COPD) following exposure to ambient particulate matter (PM) is largely unknown.

    Authors: Naijian Li, Zhaowei Yang, Baoling Liao, Tianhui Pan, Jinding Pu, Binwei Hao, Zhenli Fu, Weitao Cao, Yuming Zhou, Fang He, Bing Li and Pixin Ran

    Citation: Respiratory Research 2020 21:271

    Content type: Research

    Published on:

  11. Fibrotic interstitial lung disease (ILD) is often associated with poor outcomes, but has few predictors of progression. Daily home spirometry has been proposed to provide important information about the clinic...

    Authors: Tobias Veit, Michaela Barnikel, Alexander Crispin, Nikolaus Kneidinger, Felix Ceelen, Paola Arnold, Dieter Munker, Magdalena Schmitzer, Jürgen Barton, Sanziana Schiopu, Herbert B. Schiller, Marion Frankenberger, Katrin Milger, Jürgen Behr, Claus Neurohr and Gabriela Leuschner

    Citation: Respiratory Research 2020 21:270

    Content type: Research

    Published on:

  12. JUUL, an electronic nicotine delivery system (ENDS), which first appeared on the US market in 2015, controled more than 75% of the US ENDS sales in 2018. JUUL-type devices are currently the most commonly used ...

    Authors: Rakeysha Pinkston, Hasan Zaman, Ekhtear Hossain, Arthur L. Penn and Alexandra Noël

    Citation: Respiratory Research 2020 21:269

    Content type: Research

    Published on:

  13. Despite treatment with standard-of-care medications, including currently available biologic therapies, many patients with severe asthma have uncontrolled disease, which is associated with a high risk of hospit...

    Authors: Andrew Menzies-Gow, Michael E. Wechsler and Chris E. Brightling

    Citation: Respiratory Research 2020 21:268

    Content type: Commentary

    Published on:

  14. Despite improvement in lung function, most lung transplant (LTx) recipients show an unexpectedly reduced exercise capacity that could be explained by persisting peripheral muscle dysfunction of multifactorial ...

    Authors: Fausto Braccioni, Daniele Bottigliengo, Andrea Ermolao, Marco Schiavon, Monica Loy, Maria Rita Marchi, Dario Gregori, Federico Rea and Andrea Vianello

    Citation: Respiratory Research 2020 21:267

    Content type: Research

    Published on:

  15. Patients with severe, uncontrolled asthma have a significant unmet need for new treatments that have broader effects on airway inflammation, and that provide greater improvements in asthma outcomes than curren...

    Authors: Andrew Menzies-Gow, Gene Colice, Janet M. Griffiths, Gun Almqvist, Sandhia Ponnarambil, Primal Kaur, Gennaro Ruberto, Karin Bowen, Åsa Hellqvist, May Mo and Esther Garcia Gil

    Citation: Respiratory Research 2020 21:266

    Content type: Study protocol

    Published on:

  16. Patients with severe, uncontrolled asthma, particularly those with a non-eosinophilic phenotype, have a great unmet need for new treatments that act on a broad range of inflammatory pathways in the airway. Tez...

    Authors: Claire Emson, Sarah Diver, Latifa Chachi, Ayman Megally, Cherrie Small, John Downie, Jane R. Parnes, Karin Bowen, Gene Colice and Chris E. Brightling

    Citation: Respiratory Research 2020 21:265

    Content type: Study protocol

    Published on:

  17. Many patients with severe asthma continue to experience asthma symptoms and exacerbations despite standard-of-care treatment. A substantial proportion of these patients require long-term treatment with oral co...

    Authors: Michael E. Wechsler, Gene Colice, Janet M. Griffiths, Gun Almqvist, Tor Skärby, Teresa Piechowiak, Primal Kaur, Karin Bowen, Åsa Hellqvist, May Mo and Esther Garcia Gil

    Citation: Respiratory Research 2020 21:264

    Content type: Study protocol

    Published on:

  18. Long-term treatment with corticosteroids causes loss of bone density, but the effects of using short-term high-dose systemic-corticosteroid therapy to treat acute exacerbations of chronic obstructive pulmonary...

    Authors: Pradeesh Sivapalan, Niklas R. Jørgensen, Alexander G. Mathioudakis, Josefin Eklöf, Therese Lapperre, Charlotte Suppli Ulrik, Helle F. Andreassen, Karin Armbruster, Praleene Sivapalan, Julie Janner, Nina Godtfredsen, Ulla M. Weinreich, Thyge L. Nielsen, Niels Seersholm, Torgny Wilcke, Philipp Schuetz…

    Citation: Respiratory Research 2020 21:263

    Content type: Research

    Published on:

  19. Mitochondrial damage and dysfunction have been reported in airway and quadriceps muscle cells of patients with chronic obstructive pulmonary disease (COPD). We determined the concomitance of mitochondrial dysf...

    Authors: Gulam Haji, Coen H. Wiegman, Charalambos Michaeloudes, Mehul S. Patel, Katrina Curtis, Pankaj Bhavsar, Michael I. Polkey, Ian M. Adcock and Kian Fan Chung

    Citation: Respiratory Research 2020 21:262

    Content type: Research

    Published on:

  20. COVID-19 is a complex and heterogeneous disease. The pathogenesis and the complications of the disease are not fully elucidated, and increasing evidence shows that SARS-CoV-2 causes a systemic inflammatory dis...

    Authors: Stefano Aliberti, Francesco Amati, Maria Pappalettera, Marta Di Pasquale, Alice D’Adda, Marco Mantero, Andrea Gramegna, Edoardo Simonetta, Anna Maria Oneta, Emilia Privitera, Andrea Gori, Giorgio Bozzi, Flora Peyvandi, Francesca Minoia, Giovanni Filocamo, Chiara Abbruzzese…

    Citation: Respiratory Research 2020 21:260

    Content type: Review

    Published on:

  21. Both glaucoma and obstructive sleep apnea (OSA) are widespread diseases. OSA may presumably partly cause or worsen glaucoma, although the etiopathogenesis is unclear. Here we analyze for the first time the pos...

    Authors: Katharina Bahr, Michael Bopp, Waeel Kewader, Henri Dootz, Julia Döge, Tilman Huppertz, Perikles Simon, Verena Prokosch-Willing, Christoph Matthias and Haralampos Gouveris

    Citation: Respiratory Research 2020 21:258

    Content type: Research

    Published on:

  22. Coronavirus Disease 2019 (COVID-19) spread rapidly around the world. We aimed to describe the epidemiological characteristics and the entire evolution of COVID-19 in Wuhan, and to evaluate the effect of non-ph...

    Authors: Dongming Wang, Jing Cai, Tingming Shi, Yang Xiao, Xiaobing Feng, Meng Yang, Wenzhen Li, Wei Liu, Linling Yu, Zi Ye, Tao Xu, Jixuan Ma, Mingyan Li and Weihong Chen

    Citation: Respiratory Research 2020 21:257

    Content type: Research

    Published on:

  23. Glucocorticoids (GCs) and β2-adrenergic receptor (β2AR) agonists improve asthma outcomes in most patients. GCs also modulate gene expression in human airway smooth muscle (HASM), thereby attenuating airway inflam...

    Authors: Elena Chung, Christie A. Ojiaku, Gaoyuan Cao, Vishal Parikh, Brian Deeney, Shengjie Xu, Serena Wang, Reynold A. Panettieri Jr and Cynthia Koziol-White

    Citation: Respiratory Research 2020 21:256

    Content type: Research

    Published on:

  24. Lung ultrasound (LUS) in combination with a biomarker has not yet been studied. We propose a clinical trial where the primary aims are: 1. To assess whether an algorithm with LUS and procalcitonin (PCT) may be...

    Authors: Javier Rodríguez-Fanjul, Carmina Guitart, Sara Bobillo-Perez, Mònica Balaguer and Iolanda Jordan

    Citation: Respiratory Research 2020 21:255

    Content type: Study protocol

    Published on:

  25. Previous studies suggested that the prone position (PP) improves oxygenation and reduces mortality among patients with acute respiratory distress syndrome (ARDS). However, the mechanism of this clinical benefi...

    Authors: Kyung Min Shin, Jiwoong Choi, Kum Ju Chae, Gong Yong Jin, Ali Eskandari, Eric A. Hoffman, Chase Hall, Mario Castro and Chang Hyun Lee

    Citation: Respiratory Research 2020 21:254

    Content type: Research

    Published on:

  26. Manual auscultation to detect abnormal breath sounds has poor inter-observer reliability. Digital stethoscopes with artificial intelligence (AI) could improve reliable detection of these sounds. We aimed to in...

    Authors: Ajay Kevat, Anaath Kalirajah and Robert Roseby

    Citation: Respiratory Research 2020 21:253

    Content type: Research

    Published on:

  27. SARS-CoV-2 is causing a pandemic with currently > 29 million confirmed cases and > 900,000 deaths worldwide. The locations and mechanisms of virus entry into the human respiratory tract are incompletely charac...

    Authors: Magdalena Matusiak and Christian M. Schürch

    Citation: Respiratory Research 2020 21:252

    Content type: Letter to the Editor

    Published on:

  28. The association between diurnal temperature range (DTR) and hospitalization for exacerbation of chronic respiratory diseases (CRD) was rarely reported.

    Authors: Zihui Wang, Yumin Zhou, Ming Luo, Huajing Yang, Shan Xiao, Xiaoliang Huang, Yubo Ou, Yongbo Zhang, Xianzhong Duan, Wei Hu, Chenghao Liao, Yijia Zheng, Long Wang, Min Xie, Longhui Tang, Jinzhen Zheng…

    Citation: Respiratory Research 2020 21:251

    Content type: Research

    Published on:

  29. The role of the ATP binding cassette transporter A1 (ABCA1) in maintaining cellular lipid homeostasis in cardiovascular disease is well established. More recently, the important beneficial role played by ABCA1...

    Authors: Patrick He, Ingrid C. Gelissen and Alaina J. Ammit

    Citation: Respiratory Research 2020 21:250

    Content type: Review

    Published on:

  30. In the article “The pathophysiology of ‘happy’ hypoxemia in COVID-19,” Dhont et al. (Respir Res 21:198, 2020) discuss pathophysiological mechanisms that may be responsible for the absence of dyspnea in patient...

    Authors: Martin J. Tobin, Amal Jubran and Franco Laghi

    Citation: Respiratory Research 2020 21:249

    Content type: Letter to the Editor

    Published on:

  31. Indacaterol maleate delivered with the Breezhaler® inhalation device is a long-acting β2-agonist approved for chronic obstructive pulmonary disease. In the development of a once daily, inhaled fixed dose combinat...

    Authors: David Miller, Soniya Vaidya, Juergen Jauernig, Brian Ethell, Kristina Wagner, Rajkumar Radhakrishnan and Hanns-Christian Tillmann

    Citation: Respiratory Research 2020 21:248

    Content type: Research

    Published on:

  32. Ambient air pollution can contribute to the development and exacerbation of COPD. However, the influence of air pollution on objective COPD phenotypes, especially from imaging, is not well studied. We investig...

    Authors: Sung Ok Kwon, Seok Ho Hong, Young-Ji Han, So Hyeon Bak, Junghyun Kim, Mi Kyeong Lee, Stephanie J. London, Woo Jin Kim and Sun-Young Kim

    Citation: Respiratory Research 2020 21:247

    Content type: Research

    Published on:

  33. This study evaluated the efficacy, safety and tolerability of the novel inhaled phosphodiesterase-4 inhibitor CHF6001 added-on to formoterol in patients with chronic obstructive pulmonary disease (COPD).

    Authors: Dave Singh, Aida Emirova, Catherine Francisco, Debora Santoro, Mirco Govoni and Marie Anna Nandeuil

    Citation: Respiratory Research 2020 21:246

    Content type: Research

    Published on:

  34. The COVID-19 pandemic has led to more than 760,000 deaths worldwide (correct as of 16th August 2020). Studies suggest a hyperinflammatory response is a major cause of disease severity and death. Identitfying C...

    Authors: H. Burke, A. Freeman, D. C. Cellura, B. L. Stuart, N. J. Brendish, S. Poole, F. Borca, H. T. T. Phan, N. Sheard, S. Williams, C. M. Spalluto, K. J. Staples, T. W. Clark and T. M. A. Wilkinson

    Citation: Respiratory Research 2020 21:245

    Content type: Research

    Published on:

  35. Bronchopulmonary dysplasia (BPD) is the most common complication of prematurity and significantly contributes to mortality and morbidity with few predictive biomarkers. Given that nitrites have been implicated...

    Authors: Samuel J. Gentle, Amelia Freeman, Rakesh P. Patel, Namasivayam Ambalavanan and Charitharth V. Lal

    Citation: Respiratory Research 2020 21:244

    Content type: Letter to the Editor

    Published on:

  36. To explain the excess cardiovascular mortality observed in the SERVE-HF study, it was hypothesized that the high-pressure ASV default settings used lead to inappropriate ventilation, cascading negative consequ...

    Authors: Dany Jaffuel, Claudio Rabec, Carole Philippe, Jean-Pierre Mallet, Marjolaine Georges, Stefania Redolfi, Alain Palot, Carey M. Suehs, Erika Nogue, Nicolas Molinari and Arnaud Bourdin

    Citation: Respiratory Research 2020 21:243

    Content type: Research

    Published on:

  37. Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States with no effective treatment. The current diagnostic method, spirometry, does not accurately reflect the sev...

    Authors: Ding Liu, Maureen Meister, Shiying Zhang, Chi-In Vong, Shuaishuai Wang, Ruixie Fang, Lei Li, Peng George Wang, Pierre Massion and Xiangming Ji

    Citation: Respiratory Research 2020 21:242

    Content type: Research

    Published on:

  38. Patients with cardiovascular comorbidities are at high risk of poor outcome from COVID-19. However, how the burden (number) of vascular risk factors influences the risk of severe COVID-19 disease remains unres...

    Authors: Houwei Du, Xiaobin Pan, Nan Liu, Junnian Chen, Xiaoling Chen, David J. Werring, Gareth Ambler, Xiaoqing Li, Ronghua Chen, Yixian Zhang, Huayao Huang, Feifei Lin, Pincang Xia, Chao Chen, Zhenyang Zheng, Sangru Wu…

    Citation: Respiratory Research 2020 21:241

    Content type: Research

    Published on:

  39. Smoking-related chronic obstructive pulmonary disease (COPD) is associated with dysregulated production of mucus. Mucins (MUC) are important both for mucus secretion and epithelial defense. We have examined th...

    Authors: Heta Merikallio, Riitta Kaarteenaho, Sara Lindén, Médea Padra, Reza Karimi, Chuan-Xing Li, Elisa Lappi-Blanco, Åsa M. Wheelock and Magnus C. Sköld

    Citation: Respiratory Research 2020 21:239

    Content type: Research

    Published on:

  40. Chronic obstructive pulmonary disease (COPD) is characterised by progressive airflow limitation and chronic inflammation. Predicting exacerbations of COPD, which contribute to disease progression, is important...

    Authors: Dave Singh, Jadwiga A. Wedzicha, Salman Siddiqui, Alberto de la Hoz, Wenqiong Xue, Helgo Magnussen, Marc Miravitlles, James D. Chalmers and Peter M. A. Calverley

    Citation: Respiratory Research 2020 21:240

    Content type: Research

    Published on:

  41. Previously, it has been shown that obesity is a risk factor for recovery, regeneration, and tissue repair after blunt trauma and can affect the rate of muscle recovery and collagen deposition after trauma. To ...

    Authors: Pengfei Xu, Fabian Gärtner, Adrian Gihring, Congxing Liu, Timo Burster, Martin Wabitsch, Uwe Knippschild and Stephan Paschke

    Citation: Respiratory Research 2020 21:238

    Content type: Research

    Published on:

  42. Pentraxin 3 (PTX3) regulates multiple aspects of innate immunity and tissue inflammation. Recently, it has been reported that PTX3 deficiency enhances interleukin (IL)-17A–dominant pulmonary inflammation in an...

    Authors: Pengfei Gao, Kun Tang, Yanjiao Lu, Zhenli Huang, Shanshan Wang, Meijia Wang, Jianmiao Wang, Jianping Zhao and Jungang Xie

    Citation: Respiratory Research 2020 21:237

    Content type: Research

    Published on:

  43. Spontaneous pneumothorax is an uncommon complication of COVID-19 viral pneumonia. The exact incidence and risk factors are still unknown. Herein we review the incidence and outcomes of pneumothorax in over 300...

    Authors: Massa Zantah, Eduardo Dominguez Castillo, Ryan Townsend, Fusun Dikengil and Gerard J. Criner

    Citation: Respiratory Research 2020 21:236

    Content type: Research

    Published on:

  44. Heat shock protein 47 (HSP47), a collagen-binding protein, has a specific role in the intracellular processing of procollagen production. HSP47 expression is associated with cancer growth and metastasis in sev...

    Authors: Takuto Miyamura, Noriho Sakamoto, Kaori Ishida, Tomoyuki Kakugawa, Hirokazu Taniguchi, Yoshiko Akiyama, Daisuke Okuno, Atsuko Hara, Takashi Kido, Hiroshi Ishimoto, Takuro Miyazaki, Keitaro Matsumoto, Tomoshi Tsuchiya, Hiroyuki Yamaguchi, Taiga Miyazaki, Yasushi Obase…

    Citation: Respiratory Research 2020 21:234

    Content type: Research

    Published on:

  45. The airway epithelium (AE) forms the first line of defence against harmful particles and pathogens. Barrier failure of the airway epithelium contributes to exacerbations of a range of lung diseases that are co...

    Authors: Jon Petur Joelsson, Jennifer A. Kricker, Ari J. Arason, Snaevar Sigurdsson, Bryndis Valdimarsdottir, Fridrik Runar Gardarsson, Clive P. Page, Fredrik Lehmann, Thorarinn Gudjonsson and Saevar Ingthorsson

    Citation: Respiratory Research 2020 21:233

    Content type: Research

    Published on:

  46. Navafenterol (AZD8871) is an inhaled long-acting dual-pharmacology muscarinic antagonist/β2-adrenoceptor agonist (MABA) in development for the treatment of obstructive airways diseases. The safety, tolerability, ...

    Authors: Eulalia Jimenez, Carol Astbury, Muna Albayaty, Ulrika Wählby-Hamrén, Beatriz Seoane, Cristina Villarroel, Helena Pujol, Maria Jesus Bermejo, Ajay Aggarwal and Ioannis Psallidas

    Citation: Respiratory Research 2020 21(Suppl 1):211

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 21 Supplement 1

  47. Navafenterol (AZD8871) is a dual-pharmacology muscarinic antagonist β2−agonist (MABA) molecule in development for the treatment of chronic obstructive pulmonary disease (COPD). The pharmacodynamics, safety and to...

    Authors: Dave Singh, Victor Balaguer, Carol Astbury, Ulrika Wählby-Hamrén, Eulalia Jimenez, Beatriz Seoane, Cristina Villarroel, Alejhandra Lei, Ajay Aggarwal and Ioannis Psallidas

    Citation: Respiratory Research 2020 21(Suppl 1):102

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 21 Supplement 1

Annual Journal Metrics