Skip to main content

Table 2 Systemic availability of budesonide and fluticasone

From: The bioavailability and airway clearance of the steroid component of budesonide/formoterol and salmeterol/fluticasone after inhaled administration in patients with COPD and healthy subjects: a randomized controlled trial

A)

    

ICS

Subject group

n

AUC (μM·hr) geometric mean

CV

Budesonide

Healthy subjects

24

6.21

32.7

 

Severe COPD patients

24

3.07

106.4

Fluticasone

Healthy subjects

26

1.50

42.5

 

Severe COPD patients

23

0.84

46.0

B)

    

Parameter

Dose-adjusted AUC geometric mean ratio

95% CI

HS/COPD for BUD

2.02

1.48, 2.76

HS/COPD for FLU

1.80

1.32, 2.45

FLU/BUD for HS/COPD

0.89

0.58, 1.37

  1. Summary of A) geometric means of area under the curve (AUC) for budesonide and fluticasone and B) geometric mean ratios for dose-adjusted AUC
  2. BUD = budesonide; CI = confidence interval; CV = coefficient of variation; FLU = fluticasone; HS = healthy subjects.
Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us