Figure 5

Molecular profile of functional markers in the lung parenchyma of TS induced SH rats. CC10 (A, B), p-p38 (C, D) and SP-D (E, F) expression were examined in the lung parenchyma after FA (A, C, E) and TS (B, D, F) exposure. After FA exposure, CC10 was only seen in the parenchyma in occasional alveolar macrophages and type II pneumocytes. The image shown in A includes a transitional airway to demonstrate normal Clara cell staining. After TS exposure, CC10 was now seen more diffusely in the alveolar bed in type II cells and alveolar macrophages (B). p-p38 (C) and SP-D (E) were observed in macrophages and type II pneumocytes within the alveolar bed in FA exposed SH rats and staining pattern appeared more extensive after TS exposure and included type I pneumocytes (D, F).