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Figure 3 | Respiratory Research

Figure 3

From: Activated mammalian target of rapamycin is associated with T regulatory cell insufficiency in nasal polyps

Figure 3

Rapamycin increases the percentages of Tregs in cultured nasal polyps analyzed by flow cytometry. Representative two-dimension scatter diagrams of CD4, CD25, and Foxp3 are shown (A) and we found that rapamycin treatment is associated with an increase in Foxp3+ Tregs in cultured nasal polyps(B). Significant changes in CD4+CD25+ and Foxp3+CD4+ cells were observed during multiple comparisons (P < 0.0125 by the ANOVA test and Bonferroni correction). The percentages of CD4+CD25+ and Foxp3+CD4+ cells significantly were decreased in nasal polyps, compared to the control (Figure 3) (*P < 0.05 by the unpaired t-test for intergroup comparison). After treatment with rapamycin, a significant increase in the frequencies of CD4+CD25+ cells and Foxp3+CD4+ Tregs was found in nasal polyps (**P < 0.05 by the paired t-test for intragroup comparison).

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Respiratory Research

ISSN: 1465-993X

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