Figure 3
From: Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation
Lung IR injury is attenuated by A 2A AR activation. Lung vascular permeability was assessed by measuring BSA concentration in BAL fluid (A). Lung edema was assessed by measuring wet/dry weight ratio (B). Significant lung injury (increased vascular permeability and edema) occurred after IR in WT mice which was attenuated by ATL313 treatment. Significant lung injury also occurred in A2AAR KO mice after IR, but ATL313 had no affect on A2AAR KO lungs. WT Sham, WT lungs undergoing perfusion only; WT IR, WT lungs undergoing IR; KO IR, A2AAR KO lungs undergoing IR; KO IR+ATL313, A2AAR KO IR lungs treated with ATL313 (30 nM) during reperfusion. *p < 0.001 IR vs. WT Sham; #p < 0.01 WT IR+ATL313 vs. WT IR.