Skip to main content
Figure 3 | Respiratory Research

Figure 3

From: Endothelial cells and pulmonary arterial hypertension: apoptosis, proliferation, interaction and transdifferentiation

Figure 3

Sequence of events in HPMVEC that lead from VEGF blockade by SU5416 to transdifferentiation to smooth muscle-like cells. Endothelial cell death induced by VEGF receptor blockade and subsequent selection of progenitor-like cells leads to transdifferentiation to smooth muscle-like cells and neuronal cell. Dotted arrows mean hypothetical sequences of events. Definition of abbreviations: HPMVEC = human pulmonary microvascular endothelial cell; VSMC = vascular smooth muscle cell; SU5416 = a combined VEGF I and II receptor blocker.

Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us