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Table 2 Expression of MMP-12 and TIMP-1 upon subacute and chronic air or CS-exposure in lungs of WT and Ptx3 KO mice

From: Cigarette smoke induces PTX3 expression in pulmonary veins of mice in an IL-1 dependent manner

4 weeks

 

WT-Air

WT-CS

Ptx3 KO-Air

Ptx3 KO-CS

MMP-12/HPRT mRNA

0.11 ± 0.14

1.91 ± 0.43**

0.09 ± 0.01

1.56 ± 0.17**

TIMP-1/HPRT mRNA

0.44 ± 0.05

1.47 ± 0.32*

0.45 ± 0.03

1.12 ± 0.06**

Ratio MMP-12/TIMP-1

0.25

1.30

0.2

1.39

24 weeks

 

WT-Air

WT-CS

Ptx3 KO-Air

Ptx3 KO-CS

MMP-12/HPRT mRNA

0.10 ± 0.01

1.66 ± 0.16**

0.10 ± 0.01

1.91 ± 0.43**

TIMP-1/HPRT mRNA

0.72 ± 0.10

1.34 ± 0.10**

0.56 ± 0.05

1.20 ± 0.10**

Ratio MMP-12/TIMP-1

0.14

1.24

0.18

1.60

  1. Data are presented as mean ± SEM. WT: wild-type, Ptx3 KO: Ptx3 knockout, CS: cigarette smoke.
  2. * p < 0.05 and ** p < 0.01 versus air-exposed mice of same genotype
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Respiratory Research

ISSN: 1465-993X

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