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Table 1 Functional potencies and maximal effects of human hemokinin-1 and various tachykinin peptides on guinea-pig trachea.

From: Expression and function of human hemokinin-1 in human and guinea pig airways

Agonist

N

pD2

Emax (% of Ach 3 mM)

hHK-1

12

6.4 ± 0.03

73 ± 5

EKA/B

6

ND

ND

SP

12

6.7 ± 0.1

84 ± 2

[Sar9,Met(O2)11] SP

12

7.5 ± 0.1

76 ± 2

NKA

6

8.1 ± 0.1

95 ± 2

[β-Ala8]-NKA (4-10)

6

8.3 ± 0.6

80 ± 5

  1. hHK-1: human hemokinin-1, EKA/B: endokinin A/B, SP: substance P, NKA: neurokinin A
  2. ND: not determined because an asymptote was not reached with the highest concentration (1 μM) applied.
  3. Values are presented as pD2 and percentage of maximal contraction obtained with Ach 3 mM (mean ± s.e.m.) for n determinations.
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Respiratory Research

ISSN: 1465-993X

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