Skip to main content
Figure 4 | Respiratory Research

Figure 4

From: Effect of neutrophil elastase and its inhibitor EPI-hNE4 on transepithelial sodium transport across normal and cystic fibrosis human nasal epithelial cells

Figure 4

Effect of hNE on transepithelial Na + transport across control and CF HNEC treated with aprotinin. HNEC from control (panel A) and CF (ΔF508) (panel B) patients grown on Snapwell filters and mounted in Ussing chamber were exposed apically to vehicle, aprotinin (50 μg/ml), or aprotinin (for 90 min) followed by hNE (33 μg/ml). ΔI sc was calculated as the difference between the value of short-circuit current (I sc) at the end of exposure to drug or vehicle and the baseline I sc at the moment of drug or vehicle addition. Results are expressed in μA/cm2 and represent means ± SE of four to ten filters for each condition. **, ***: significantly different from vehicle (P < 0.01 and P < 0.001, respectively); §, §§: significantly different from aprotinin alone (P < 0.05 and P < 0.01, respectively).

Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us