Table 3 Effects of treatment with salmeterol and fluticasone on mortality
| Â | Â | Â | Â | Â | Main effect* | |||
|---|---|---|---|---|---|---|---|---|
Factor | Placebo (A) | Salmeterol (B) | Fluticasone (C) | Salmeterol plus fluticasone (D) | Salmeterol received | Fluticasone received | ||
| Â | Â | Â | Â | Â | Yes (B+D) | No (A+C) | Yes (C+D) | No (A+B) |
No. of subjects | 1,524 | 1,521 | 1,534 | 1,533 | 3,054 | 3,058 | 3,067 | 3,045 |
No. of deaths | 231 | 205 | 246 | 193 | 398 | 477 | 439 | 436 |
Probability of deaths at 3 years (%) | 15.2 | 13.5 | 16.0 | 12.6 | 13.0 | 15.6 | 14.3 | 14.3 |
Hazard ratio (95% confidence interval) | Â | Â | Â | Â | 0.81 (0.70-0.94) | Â | 1.00 (0.87-1.15) | Â |
Chi-square | Â | Â | Â | Â | 8.20 | Â | 0.00 | Â |
P value | Â | Â | Â | Â | 0.004 | Â | 0.99 | Â |