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Figure 2 | Respiratory Research

Figure 2

From: The laminin β1-competing peptide YIGSR induces a hypercontractile, hypoproliferative airway smooth muscle phenotype in an animal model of allergic asthma

Figure 2

Topical treatment of the airways with YIGSR increases ASM contractility and contractile protein accumulation. (A) Treatment with YIGSR enhanced the maximal methacholine-induced isometric contraction of epithelium-denuded tracheal smooth muscle preparations both in saline- and in ovalbumin-challenged animals. (B) Treatment with YIGSR increased pulmonary expression of sm-MHC, both in saline- and in ovalbumin-challenged animals. Representative blots of sm-MHC and β-actin are shown. ***P < 0.001 compared to saline-treated, saline-challenged controls. ##P < 0.01 compared to saline-treated, ovalbumin-challenged controls. Data represent means ± SEM of 5-7 animals.

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Respiratory Research

ISSN: 1465-993X

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