Selective accumulation of langerhans-type dendritic cells in small airways of patients with COPD

Respiratory Research

Table 2 Expression of Surface Markers on interstitial-type and langerhans-type DC (flowcytometric analysis of lung digest)

Surface marker	% positive cells			Mean Fluorescence Intensity
	intDC	LDC	p	intDC	LDC	p
BDCA-1	6.3 [1.7-9.6]	72.6 [42.1-81.7]	**	9.6 [3.1-16.5]	60.2 [48.3-140.0]	**
CD1a	3.1 [0.3-5.2]	54.1 [23.0-73.8]	*	13.4 [4.4-30.3]	112.4 [38.2-203.0]	*
BDCA-3	54.3 [13.5-98.1]	56.2 [3.2-97.3]	ns	54.0 [44.3-168.0]	35.4 [21.2-156.0]	ns
BDCA-4	15.0 [1.9-57.1]	4.6 [0.0-15.0]	ns	33.0 [8.6-89.6]	14.5 [8.6-38.5]	ns
CD163	4.5 [3.0-46.2]	4.3 [0.6-26.8]	ns	27.1 [11.9-186.0]	20.0 [3.7-127.0]	ns
CD14	57.2 [20.4-81.5]	10.2 [2.5-23.1]	*	56.3 [11.5-207.0]	12.6 [3.6-87.8]	ns
HLA-DR	56.3 [21.4-98.5]	88.7 [73.1-98.7]	ns	132.0 [31.7-2399]	544.0 [484.0-1629.0]	ns

Data are expressed as median [range]
intDC: interstitial-type dendritic cell; LDC: langerhans-type dendritic cell
p value compairing two groups (Mann-Whitney-U test): *: p < 0.05; **: p < 0.01; ns: not significant

ISSN: 1465-993X