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Table 7 Prognostic outcomes according to different COPD definitions in univariate Cox regression analysis

From: "GOLD or lower limit of normal definition? a comparison with expert-based diagnosis of chronic obstructive pulmonary disease in a prospective cohort-study"

COPD definition

Exacerbations of COPD

HR (95% CI) P

Hospitalisation for

pulmonary reason

HR (95% CI) P

All-cause

death

HR (95% CI) P

Expert panel (N = 247)

2.94 (1.99;4.31) P < 0.001

2.03 (1.18;3.49) P = 0.010

3.59 (1.82;7.07) P < 0.001

GOLD-COPD (N = 244)

2.92 (1.99;4.28) P < 0.001

1.62 (0.97;2.72) P = 0.067

1.81 (1.03;3.17) P = 0.038

LLN: Enright [16] (N = 142)

2.70 (1.95;3.73) P < 0.001

2.20 (1.36;3.55) P = 0.001

2.28 (1.37;3.78) P = 0.001

LLN: Quanjer [14] (N = 167)

2.97 (2.14;4.14) P < 0.001

2.06 (1.27;3.33) P = 0.003

2.21 (1.32;3.70) P = 0.002

LLN: Falaschetti [17] (N = 175)

2.89 (2.07;4.03) P < 0.001

1.87 (1.15;3.03) P = 0.011

2.02 (1.21;3.38) P = 0.007

  1. Univariate Cox Regression analysis comparing COPD yes versus no diagnosis per definition. N corresponds to the number of patients with COPD according to the different definitions of COPD.
  2. Abbreviations:
  3. CI, Confidence interval, HR, Hazard ratio, FN, false negative, FP, false positive, TN, true negative, TP, true positive.
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Respiratory Research

ISSN: 1465-993X

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