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Table 1 Changes in matrix protein gene expression in B6 vs D2 mice

From: Strain variation in response to lung ischemia: role of MMP-12

 

B6

D2

 

3d LPAL

14d LPAL

Naïve

3d LPAL

14d LPAL

Structural genes

     

Col1a1

1.3 ± 0.1

1.4 ± 0.2

1.1 ± 0.1

2.1 ± 0.6

1.6 ± 0.2

Col3a1

1.4 ± 0.0

1.2 ± 0.2

1.6 ± 0.0

1.7 ± 0.1

1.7 ± 0.2

Col6a3

1.3 ± 0.1

1.7 ± 0.2

1.1 ± 0.2

1.7 ± 0.4

2.2 ± 0.5

Eln

1.8 ± 0.2

3.0 ± 0.5*

0.5 ± 0.1*

2.4 ± 0.8

3.5 ± 0.5*

Fbn1

1.1 ± 0.2

1.1 ± 0.1

0.9 ± 0.1

2.2 ± 1.0

1.4 ± 0.1

Fn1

1.3 ± 0.1

1.3 ± 0.2

1.3 ± 0.3

1.5 ± 0.2

1.3± 0.1

Protease genes

     

MMP-2

1.0 ± 0.1

1.9 ± 0.2*

20.1 ± 1.0*

0.9 ± 0.2

1.5 ± 0.1

MMP-9

1.3 ± 0.2

0.5 ± 0.2

0.9 ± 0.1

1.3 ± 0.3

0.4 ± 0.0*

MMP-12

3.6 ± 0.7*

1.7 ± 0.1

3.2 ± 0.5*

2.0 ± 0.8

2.9 ± 1.2

MMP-14

2.0 ± 0.1*

1.5 ± 0.2

1.0 ± 0.1

2.7 ± 0.8

2.0 ± 0.3

Ctsk

1.3 ± 0.1

1.8 ± 0.3

1.6 ± 0.1

1.1 ± 0.2

1.7 ± 0.2

Anti-protease genes

     

Timp1

8.8 ± 0.6*

1.5 ± 0.2

0.8 ± 0.0

19.6 ± 2.9*

3.8 ± 0.1*

Timp2

0.7 ± 0.1

0.9 ± 0.0

1.5 ± 0.1

0.8 ± 0.2

1.5 ± 0.1

Timp3

0.7 ± 0.1

1.0 ± 0.0

1.7 ± 0.2

1.1 ± 0.3

2.4 ± 0.2*

Timp4

0.5 ± 0.1

0.6 ± 0.1

0.6 ± 0.1

1.2 ± 0.1

2.5 ± 0.4*

  1. Expression of matrix-associated genes (* indicates p < 0.01). All comparisons were made versus B6 naïve left lungs.
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Respiratory Research

ISSN: 1465-993X

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