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Table 3 Sensitivity and specificity of response to mannitol compared to hypertonic saline and a clinical assessment of asthma (Clinical Dx)

From: The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase 3 comparison study with hypertonic (4.5%) saline

 

Sensitivity (95% CI)

Specificity (95% CI)

Mannitol vs Hypertonic Saline

80.7 (76.4, 85.1)

86.7 (82.6, 90.7)

Mannitol vs Clinical Dx

59.8 (55.4, 64.2)

94.5 (89.9, 99.2)

Hypertonic Saline vs Clinical Dx

65.1 (60.9, 69.3)

95.2 (91.1, 99.3)

Excluding all taking ICS

  

Mannitol vs Clinical Dx

70 (62.1, 78.2)

95 (90.7, 99.3)

Excluding M-ve taking ICS

  

Mannitol vs Clinical Dx

89 (85.3, 92.1)

95 (90.7, 99.3)